{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:32:12Z","timestamp":1747182732886,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Use of thromboprophylaxis effectively prevents pulmonary embolism (PE) and deaths after total hip and knee arthroplasty (THA and TKA). The optimum length of thromboprophylaxis is not known and has traditionally been based on the type of operation. Nowadays, a more individualized approach is preferred. This study analyzed if risk stratification\u2010based planning of thromboprophylaxis has an association with the all\u2010cause mortality after fast\u2010track THA and TKA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>We compared fast\u2010track THAs and TKAs operated between 2015\u20132016 and 2020\u20132021. Between 2015 and 2016, all patients received a routine length of thromboprophylaxis. From 2020 onwards, thromboprophylaxis was planned by risk stratification, and patients at low risk for venous thromboembolism received thromboprophylaxis only during hospitalization. All causes of death within 90\u2009days of surgery were identified and the incidence of mortality was calculated. Mortality rates between the two periods were then compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2015 and 2016, 3192 arthroplasties were performed. A total of eight deaths occurred within 90\u2009days of surgery, yielding an incidence of all\u2010cause mortality of 0.3% (95% CI 0.1\u20130.5). Between 2020 and 2021, a total of 3713 arthroplasties were performed to patients who received risk stratification\u2010based thromboprophylaxis. Thirteen of these patients died within 90\u2009days of surgery, yielding an all\u2010cause mortality incidence of 0.4% (95% CI 0.2\u20130.6). Cardiovascular diseases were the main cause of death during both study periods. None of the deaths were caused by PEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Risk stratification\u2010based thromboprophylaxis was not associated with increased all\u2010cause mortality within 90\u2009days of fast\u2010track THA and TKA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14414","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T01:19:05Z","timestamp":1711502345000},"page":"720-725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk stratification\u2010based thromboprophylaxis does not affect mortality after fast\u2010track hip and knee arthroplasty"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3058-6343","authenticated-orcid":false,"given":"Annette M.","family":"Moisander","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Intensive Care, Hospital Nova Wellbeing Services County of Central Finland  Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konsta","family":"Pamilo","sequence":"additional","affiliation":[{"name":"Coxa Hospital for Joint Replacement Wellbeing Services County of Pirkanmaa  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Huopio","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology Kuopio University Hospital, Wellbeing Services County of North Savo  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannu","family":"Kautiainen","sequence":"additional","affiliation":[{"name":"Primary Health Care Unit University of Eastern Finland  Kuopio Finland"},{"name":"Finland and Folkh\u00e4lsan Research Center  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Kuitunen","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Tampere University Hospital, Wellbeing Services County of Pirkanmaa  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Paloneva","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital Nova, Wellbeing Services County of Central Finland Jyv\u00e4skyl\u00e4 and University of Eastern Finland  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23197"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453674.2016.1275200"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453674.2017.1404791"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264\u2010011\u20101235\u20105"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/17453674.2022.2266"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/17453674.2022.4837"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453674.2017.1279496"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38232"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000118"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2404"},{"key":"e_1_2_10_12_1","first-page":"250","volume-title":"Recommendations on Thromboprophylaxis in Major Joint Arthroplasty \u2013 Many Guidelines, Little Consensus? 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