{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:32:12Z","timestamp":1747182732874,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005760","name":"G\u00f6teborgs Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005760","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ratio of arterial pressure of oxygen and fraction of inspired oxygen (<jats:italic>P<\/jats:italic>\/<jats:italic>F<\/jats:italic> ratio) together with the fractional dead space (<jats:italic>V<\/jats:italic><jats:sub>d<\/jats:sub>\/<jats:italic>V<\/jats:italic><jats:sub>t<\/jats:sub>) provides a global assessment of pulmonary gas exchange. The aim of this study was to assess the potential value of these variables to prognosticate 90\u2010day survival in patients with COVID\u201019 associated ARDS admitted to the Intensive Care Unit (ICU) for invasive ventilatory support.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single\u2010center observational, retrospective study, <jats:italic>P<\/jats:italic>\/<jats:italic>F<\/jats:italic> ratios and <jats:italic>V<\/jats:italic><jats:sub>d<\/jats:sub>\/<jats:italic>V<\/jats:italic><jats:sub>t<\/jats:sub> were assessed up to 4\u2009weeks after ICU\u2010admission. Measurements from the first 2\u2009weeks were used to evaluate the predictive value of <jats:italic>P<\/jats:italic>\/<jats:italic>F<\/jats:italic> ratio and <jats:italic>V<\/jats:italic><jats:sub>d<\/jats:sub>\/<jats:italic>V<\/jats:italic><jats:sub>t<\/jats:sub> for 90\u2010day mortality and reported by the adjusted hazard ratio (HR) and 95% confidence intervals [95%CI] by Cox proportional hazard regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Almost 20,000 blood gases in 130 patients were analyzed. The overall 90\u2010day mortality was 30% and using the data from the first ICU week, the HR was 0.85 [0.77\u20130.94] for every 10\u2009mmHg increase in <jats:italic>P<\/jats:italic>\/<jats:italic>F<\/jats:italic> ratio and 1.61 [1.20\u20132.16] for every 0.1 increase in <jats:italic>V<\/jats:italic><jats:sub>d<\/jats:sub>\/<jats:italic>V<\/jats:italic><jats:sub>t<\/jats:sub>. In the second week, the HR for 90\u2010day mortality was 0.82 [0.75\u20130.89] for every 10\u2009mmHg increase in <jats:italic>P<\/jats:italic>\/<jats:italic>F<\/jats:italic> ratio and 1.97 [1.42\u20132.73] for every 0.1 increase in <jats:italic>V<\/jats:italic><jats:sub>d<\/jats:sub>\/<jats:italic>V<\/jats:italic><jats:sub>t<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The progressive changes in <jats:italic>P<\/jats:italic>\/<jats:italic>F<\/jats:italic> ratio and <jats:italic>V<\/jats:italic><jats:sub>d<\/jats:sub>\/<jats:italic>V<\/jats:italic><jats:sub>t<\/jats:sub> in the first 2\u2009weeks of invasive ventilatory support for COVID\u201019 ARDS were significant predictors for 90\u2010day mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14415","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T13:29:46Z","timestamp":1712064586000},"page":"803-811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Progressive changes in pulmonary gas exchange during invasive respiratory support for <scp>COVID<\/scp>\u201019 associated acute respiratory failure: A retrospective study of the association with 90\u2010day mortality"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1542-5402","authenticated-orcid":false,"given":"Ylva","family":"Konsberg","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences the Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2096-5304","authenticated-orcid":false,"given":"Anders","family":"\u00c5neman","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences the Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Intensive Care Unit, Liverpool Hospital Southwestern Sydney Local Health District  Australia"},{"name":"South Western Clinical School University of New South Wales  Australia"},{"name":"Ingham Institute for Applied Medical Science  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6645-4177","authenticated-orcid":false,"given":"Fredrik","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences the Sahlgrenska Academy at the University of Gothenburg  Sahlgrenska Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredrik","family":"Hessulf","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences the Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt","family":"Nellg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences the Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"H\u00e5rd af Segerstad","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences the Sahlgrenska Academy at the University of Gothenburg  Sahlgrenska Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keti","family":"Dalla","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences the Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin definition","volume":"307","author":"Force ADT","year":"2012","journal-title":"JAMA"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15532"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5394"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-021-00397-5"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e318247f6cc"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012835"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214103"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021436"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/146.2.419"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.96.4.849"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.6.8520742"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.4.9704088"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.4.9802009"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-021-00908-3"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200610-1534OC"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.02593"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.08786"},{"key":"e_1_2_11_19_1","first-page":"521","article-title":"Assessing dead space. A meaningful variable?","volume":"72","author":"Hedenstierna G","year":"2006","journal-title":"Minerva Anestesiol"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc6872"},{"key":"e_1_2_11_21_1","first-page":"513","article-title":"Effect of right\u2010to\u2010left shunting on alveolar dead space","volume":"20","author":"Mecikalski MB","year":"1984","journal-title":"Bull Eur Physiopathol Respir"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02287-2022"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202002-0373LE"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.047430"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-020-02242-0"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03570-0"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06294-x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5129314"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10071-24170"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06866-2"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0254550"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2021.02.013"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.2147\/RMHP.S263095"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.14415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T11:26:32Z","timestamp":1718796392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.14415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,2]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/aas.14415"],"URL":"https:\/\/doi.org\/10.1111\/aas.14415","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"type":"print","value":"0001-5172"},{"type":"electronic","value":"1399-6576"}],"subject":[],"published":{"date-parts":[[2024,4,2]]},"assertion":[{"value":"2023-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}