{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:41:08Z","timestamp":1778726468943,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009738","name":"Anna och Edwin Bergers Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Malignant hyperthermia (MH) is a rare pharmacogenetic disorder that can lead to a life\u2010threatening reaction during general anaesthesia with triggering agents. Prompt life\u2010saving treatment includes the immediate administration of the antidote dantrolene. This study investigated Swedish healthcare providers' awareness and adherence to guidelines and recommendations with respect to MH and whether adherence to safe MH\u2010praxis varies with hospital care\u2010complexity level and private versus public management form.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Agreements and procurement specifications between all 21 Swedish County Councils and privately run surgical care providers were reviewed alongside with questionnaire\u2010aided collection of information from 62 publicly funded health care providers (both privately and publicly run).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No procurement requirement specification or contract contained requirements on anaesthesia or aspects of MH. All publicly run hospitals stocked dantrolene and 28 out of 52 (54%) stocked the recommended amount. Seven out of nine (78%) of the privately run institutions stocked dantrolene, and one stocked the recommended amount. Publicly run hospitals adhered to recommendations to a greater extent than privately run institutions, both with respect to stocking of dantrolene (<jats:italic>p<\/jats:italic>\u2009=\u2009.02) and to stocking the recommended amount (<jats:italic>p<\/jats:italic>\u2009=\u2009.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Contracts between Swedish county councils and private surgical care subcontractors rarely outline expectations of standards for the safe practice of anaesthesia such as preparedness to handle a life\u2010threatening MH reaction. Among Swedish publicly funded anaesthesia providers there is room for improvement in adherence to the EMHG guideline on dantrolene availability. Publicly run hospitals seem to have better compliance with these recommendations than privately run institutions. Raising awareness about current guidelines is important to improve safety for known and unknown MH\u2010susceptible individuals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14417","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T05:19:53Z","timestamp":1712121593000},"page":"788-793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Malignant hyperthermia safety \u2013 A nationwide survey of publicly funded Swedish healthcare"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4455-6401","authenticated-orcid":false,"given":"Anna","family":"Hellblom","sequence":"first","affiliation":[{"name":"Department of Intensive and Perioperative Care Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Department of Laboratory Medicine, Clinical Genetics Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Pettersson","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Anaesthesiology and Intensive Care Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Soller","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Genetics Lund University  Lund Sweden"},{"name":"Department of Clinical Genetics and Genomics Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Samuelsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Anaesthesiology and Intensive Care Lund University  Lund Sweden"},{"name":"Halland Hospitals, Region Halland  Halland Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)03078-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3182a8a8e7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20231"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200606000-00008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.06.010"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03004694"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181ac1548"},{"issue":"7","key":"e_1_2_10_9_1","first-page":"700","article-title":"Incidence of malignant hyperthermia in Denmark","volume":"64","author":"Ording H","year":"1985","journal-title":"Anesth Analg"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318190bb08"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq243"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.09.029"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.04.089"},{"key":"e_1_2_10_14_1","unstructured":"Malignant Hyperthermia Association of the United States.How Much Dantrolene Should be Available in Facilities Where Volatile Agents are not Available or Administered and Succinylcholine is Only Stocked on Site for Emergency Purposes? 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