{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:36:27Z","timestamp":1791286587614,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005275","name":"Region Hovedstaden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016380","name":"Bispebjerg Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Managing postoperative pain while minimizing opioid\u2010related adverse drug events (ORADEs) remains a significant challenge. The OPI\u2022AID Zone Tool is proposed as a novel clinical decision support tool that \u2010 both graphically and in a scoring\u2010system \u2010\u00a0represents the relationship between pain management and the occurrence of ORADEs, aiming to enhance patient outcomes in postoperative care. The OPI\u2022AID Zone Tool places pain score\u00a0on the x\u2010axis and an ORADE score on the y\u2010axis, and stratifies patients into five zones to reflect the composite impact of pain severity and ORADEs on the quality of postoperative patient care. The study will have two key aims: (1) to explore whether the OPI\u2022AID Zone Tool can function as a composite outcome measure for postoperative pain and ORADEs, and (2) to evaluate the use of the OPI\u2022AID Zone Tool in visual presentations and for evaluation of patients\u2019 postoperative pain management quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective observational cohort study will include 200 adults undergoing various surgical procedures in general anesthesia with a subsequent stay in the post\u2010anesthesia care unit (PACU) at Bispebjerg Hospital, Denmark.<\/jats:p><jats:p><jats:italic>Substudy 1 primary outcome<\/jats:italic>: To assess whether a zone score in the OPI\u2022AID Zone Tool is associated with patient\u2010perceived health (EQ VAS), quality of recovery (QoR\u2010PACU), and time to discharge readiness in PACU, and if the zone score has a stronger association than pain and ORADE score in themselves.<\/jats:p><jats:p><jats:italic>Substudy 2 primary outcome<\/jats:italic>: To assess how the use of intraoperative non\u2010opioid analgesics impact where patients are placed in the OPI\u2022AID Zone Tool's XY scatterplot right after surgery.<\/jats:p><jats:p>To assess if patients who receive more comprehensive non\u2010opioid analgesic basic regimens, generally fall into lower zones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The OPI\u2022AID Zone Tool could potentially be a valuable clinical decision\u2010making tool for optimizing postoperative care by simultaneously addressing pain management and the risk of ORADEs. By computing a composite measure of these two critical outcomes, the tool could guide more nuanced and patient\u2010centered analgesic regimens, potentially improving patient satisfaction and operational efficiency in postoperative settings. The tool's applicability will be explored in this observational pilot and followed up in a planned series of studies (opiaid.dk).<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14422","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T12:53:31Z","timestamp":1713358411000},"page":"960-974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The <scp>OPI<\/scp>\u2022<scp>AID<\/scp> Zone Tool as a composite outcome for postoperative pain management quality\u2014A protocol for an observational pilot study"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0338-3751","authenticated-orcid":false,"given":"Anders Peder H\u00f8jer","family":"Karlsen","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg  Copenhagen 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Christian","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Regional Health Research, The Faculty of Health Sciences University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4885-4609","authenticated-orcid":false,"given":"Christian S.","family":"Meyhoff","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troels Haxholdt","family":"Lunn","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care 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