{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:15:31Z","timestamp":1781630131610,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T00:00:00Z","timestamp":1716076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The neuromuscular blocking agent mivacurium can be used during anesthesia to facilitate tracheal intubation. Data on onset time, duration of action, and effect on intubating conditions in patients 80\u2009years and older are however limited. We hypothesized that onset time and duration of action of mivacurium would be longer in elderly patients than in younger adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective observational study included 35 elderly (\u226580\u2009years) and 35 younger (18\u201340\u2009years) patients. Induction of anesthesia comprised fentanyl 1\u20133\u2009\u03bcg\u2009kg<jats:sup>\u22121<\/jats:sup> and propofol 1.5\u20132.5\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> and propofol and remifentanil for maintenance. Acceleromyography was used for monitoring neuromuscular blockade. The primary outcome was onset time defined as time from injection of mivacurium 0.2\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> to a train\u2010of\u2010four (TOF) count of zero. Other outcomes included duration of action (time to TOF ratio\u2009\u22650.9), intubating conditions using the Fuchs\u2010Buder scale and the intubating difficulty scale (IDS), and occurrence of hoarseness and sore throat postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No difference was found in onset time comparing elderly with younger patients; 219\u2009s (SD 45) versus 203\u2009s (SD 74) (difference: 16\u2009s (95% CI: \u221245 to 14), <jats:italic>p<\/jats:italic>\u2009=\u2009.30). Duration of action was significantly longer in elderly patients compared with younger patients; 52\u2009min (SD 17) versus 30\u2009min (SD 8) (difference: 22\u2009min [95% CI: 15 to 28], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). No difference was found in the proportion of excellent intubating conditions (Fuchs\u2010Buder); 31\/35 (89%) versus 26\/35 (74%) (<jats:italic>p<\/jats:italic>\u2009=\u2009.12) or IDS score (<jats:italic>p<\/jats:italic>\u2009=\u2009.13). A larger proportion of younger patients reported sore throat 24\u2009h postoperatively; 34% versus 0%, <jats:italic>p<\/jats:italic>\u2009=\u2009.0002. No difference was found in hoarseness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No difference in onset time of mivacurium 0.2\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> was found comparing elderly and younger patients. However, elderly patients had significantly longer duration of action. No difference was found in intubating conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14440","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T04:45:15Z","timestamp":1716180315000},"page":"898-905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Onset time, duration of action, and intubating conditions after mivacurium in elderly and younger patients"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-2725","authenticated-orcid":false,"given":"Matias","family":"Vested","sequence":"first","affiliation":[{"name":"Department of Anesthesia Centre of Head and Orthopedics, Rigshospitalet, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Kempff\u2010Andersen","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Centre of Head and Orthopedics, Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3954-8634","authenticated-orcid":false,"given":"Andreas","family":"Creutzburg","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Centre of Head and Orthopedics, Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3037-6300","authenticated-orcid":false,"given":"Helene","family":"Dalsten","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Centre of Head and Orthopedics, Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7436-3267","authenticated-orcid":false,"given":"Sarah Sofie","family":"Wadland","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Centre of Head and Orthopedics, Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1050-0792","authenticated-orcid":false,"given":"Oscar","family":"Rosenkrantz","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Centre of Head and Orthopedics, Rigshospitalet, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8800-6616","authenticated-orcid":false,"given":"Christine L.","family":"Rosager","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Herlev Hospital  Herlev Denmark"},{"name":"Danish Cholinesterase Research Unit, Department of Anesthesia Herlev Hospital  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-3004","authenticated-orcid":false,"given":"Lars S.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Danish Ministry of Defence Personnel Agency  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198805000-00010"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/69.6.580"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2002.460609.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1993.tb03721.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1993.tb07469.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199607000-00011"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2010.11.011"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000865"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.14279"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199712000-00005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/73.5.608"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03018917"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13714"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198402000-00004"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1997.084-az0080.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.11.011"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-022-01881-5"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13957"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-023-01012-6"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03008227"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13645"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31817f5bc7"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318182af3b"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.14440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T02:13:20Z","timestamp":1721960000000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.14440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,19]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/aas.14440"],"URL":"https:\/\/doi.org\/10.1111\/aas.14440","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,19]]},"assertion":[{"value":"2024-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}