{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:40:31Z","timestamp":1793054431678,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Platelet transfusions are frequently used in the intensive care unit (ICU), but current practices including used product types, volumes, doses and effects are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design and methods<\/jats:title><jats:p>Sub\u2010study of the inception cohort study \u2018Thrombocytopenia and Platelet Transfusions in the ICU (PLOT\u2010ICU)\u2019, including acutely admitted, adult ICU patients with thrombocytopenia (platelet count &lt;150\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L). The primary outcome was the number of patients receiving platelet transfusion in ICU by product type. Secondary outcomes included platelet transfusion details, platelet increments, bleeding, other transfusions and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Amongst 504 patients with thrombocytopenia from 43 hospitals in 10 countries in Europe and the United States, 20.8% received 565 platelet transfusions; 61.0% received pooled products, 21.9% received apheresis products and 17.1% received both with a median of 2 (interquartile range 1\u20134) days from admission to first transfusion. The median volume per transfusion was 253\u2009mL (180\u2013308\u2009mL) and pooled products accounted for 59.1% of transfusions, however, this varied across countries. Most centres (73.8%) used fixed dosing (medians ranging from 2.0 to 3.5\u2009\u00d7\u200910<jats:sup>11<\/jats:sup> platelets\/transfusion) whilst some (mainly in France) used weight\u2010based dosing (ranging from 0.5 to 0.7\u2009\u00d7\u200910<jats:sup>11<\/jats:sup> platelets per 10\u2009kg body weight). The median platelet count increment for a single prophylactic platelet transfusion was 2 (\u22121 to 8)\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L. Outcomes of patients with thrombocytopenia who did and did not receive platelet transfusions varied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among acutely admitted, adult ICU patients with thrombocytopenia, 20.8% received platelet transfusions in ICU of whom most received pooled products, but considerable variation was observed in product type, volumes and doses across countries. Prophylactic platelet transfusions were associated with limited increases in platelet counts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14467","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T04:29:41Z","timestamp":1717648181000},"page":"1018-1030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Platelet transfusions in adult <scp>ICU<\/scp> patients with thrombocytopenia: A sub\u2010study of the <scp>PLOT<\/scp>\u2010<scp>ICU<\/scp> inception cohort study"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7740-700X","authenticated-orcid":false,"given":"Carl Thomas","family":"Anthon","sequence":"first","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen 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Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8162-1508","authenticated-orcid":false,"given":"Elie","family":"Azoulay","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive &amp; R\u00e9animation, H\u00f4pital Saint\u2010Louis, Assistance Publique \u2013 H\u00f4pitaux de Paris Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5742-6171","authenticated-orcid":false,"given":"Kathryn","family":"Puxty","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Glasgow Royal Infirmary  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2260-2005","authenticated-orcid":false,"given":"Andry","family":"Van De Louw","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Penn State 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