{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T04:22:01Z","timestamp":1743913321553,"version":"3.40.3"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013826","name":"Candys Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Total knee arthroplasty is associated with an inflammatory response and high levels of pain in a subset of patients. Pain catastrophizing has been associated with acute postoperative pain. The association between these variables has not been investigated in an optimised fast\u2010track setup including preoperative glucocorticoids. The aim of this study was, first, to investigate the correlation between the increase in postoperative c\u2010reactive protein (CRP) and acute postoperative pain after total knee arthroplasty, and second, to investigate the correlation between the increase in CRP and preoperative pain catastrophizing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study is a secondary analysis of data from 119 patients participating in two randomised controlled trials. Correlation analyses were performed for preoperative CRP and CRP increase at 24 and 48\u2009h and pain during a well\u2010defined mobilisation at 24 and 48\u2009h after total knee arthroplasty. Additionally, correlation analyses were performed between CRP increase and pain catastrophizing using the pain catastrophizing scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no correlation between preoperative CRP or postoperative CRP increase and pain at both 24 and 48\u2009h. Analyses were similar when separated into high and low pain catastrophizers. There was no correlation between preoperative CRP or postoperative CRP increase and pain catastrophizing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was no association between the postoperative CRP response and postoperative acute pain or pain catastrophizing in patients undergoing total knee arthroplasty in a well\u2010defined multimodal fast\u2010track regime including preoperative glucocorticoids. These results suggest that acute pain after knee arthroplasty is not reflected by CRP when applying preoperative glucocorticoids.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14476","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T07:59:45Z","timestamp":1719043185000},"page":"1215-1222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative association between c\u2010reactive protein, pain catastrophizing and acute pain after total knee arthroplasty: A secondary analysis of two randomised trials"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-7050","authenticated-orcid":false,"given":"Anders H.","family":"Springborg","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Copenhagen University Hospital Hvidovre  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2209-1711","authenticated-orcid":false,"given":"Henrik","family":"Kehlet","sequence":"additional","affiliation":[{"name":"Section of Surgical Pathophysiology, 7621 Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2485-5172","authenticated-orcid":false,"given":"Niklas I.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Copenhagen University Hospital Hvidovre  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirill","family":"Gromov","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Orthopaedic Surgery Copenhagen University Hospital Hvidovre  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Troelsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Orthopaedic Surgery Copenhagen University Hospital Hvidovre  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Varnum","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Lillebaelt Hospital\u2014Vejle  Vejle Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolai B.","family":"Foss","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Copenhagen University Hospital Hvidovre  Hvidovre Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.06.011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2008.05831.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet128"},{"key":"e_1_2_10_5_1","first-page":"237","article-title":"C\u2010reactive protein (CRP) levels after elective orthopedic surgery","author":"Larsson S","year":"1992","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2004.09.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-020-04551-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.80B5.0800909"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-011-0020-1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.8.216"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S187249"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001691"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2021.10.001"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2022.10.038"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21865"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000728"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.07.024"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.7.4.524"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000597"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456329803500512"},{"key":"e_1_2_10_21_1","first-page":"3438","article-title":"Different dexamethasone doses in the perioperative period improve short\u2010term outcomes of total hip arthroplasty: a randomized controlled trial","volume":"27","author":"Li FL","year":"2023","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2018.08.033"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000000572"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-022-01938-5"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.K.00813"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.14476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T01:55:29Z","timestamp":1743904529000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.14476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,22]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/aas.14476"],"URL":"https:\/\/doi.org\/10.1111\/aas.14476","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"type":"print","value":"0001-5172"},{"type":"electronic","value":"1399-6576"}],"subject":[],"published":{"date-parts":[[2024,6,22]]},"assertion":[{"value":"2024-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}