{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:08:39Z","timestamp":1783724919397,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pre\u2010operative iron deficiency anaemia (IDA) is common in patients undergoing elective major abdominal surgery and is associated with increased risk of perioperative complications. However, widespread implementation of pre\u2010operative anaemia management is lacking. Guidelines recommend investigation of anaemia preferably 4\u20136\u2009weeks before surgery to allow time for correction. However, this is not always feasible in abdominal cancer surgery with short time to surgery and may be influenced by concomitant chemotherapy. The objective of this study was to assess the efficacy of implementing a pre\u2010operative screening and treatment programme for IDA in elective abdominal cancer surgery patients, with short duration to surgery and concomitant use of chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients scheduled for elective abdominal cancer surgery with IDA were included. Anaemia was defined according to the World Health Organization\u2010criteria and iron deficiency as a transferrin saturation &lt;0.20. The primary outcome was change in haemoglobin (Hb) between iron infusion and surgery in patients receiving pre\u2010operative intravenous iron infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 178 diagnosed IDA patients 134 (75%) received intravenous iron, 103 pre\u2010operatively (58%) at median day 17 (interquartile range: 9\u201327) before surgery while 31 (17%) received post\u2010operative intravenous iron treatment. The pre\u2010operative Hb increased 0.89\u2009g\/dL (95% CI: 0.64\u20131.13, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) compared to a decrease of 0.4\u2009g\/dL (95% CI: 0.19\u20130.58, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) in 75 patients not treated pre\u2010operatively. Patients diagnosed with severe anaemia had the largest pre\u2010operative Hb increase. Iron infusion &gt;2\u2009weeks pre\u2010operatively resulted in a greater Hb increment of 1.13\u2009g\/dL (95% CI: 0.81\u20131.45) compared to iron infusion \u22642\u2009weeks before surgery 0.48\u2009g\/dL (95% CI: 0.16\u20130.81). Hb increased by 0.64\u2009g\/dL (95% CI 0.19\u20131.21) in patients receiving chemotherapy \u226431\u2009days prior to surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients scheduled for abdominal cancer surgery, including in patients with concomitant chemotherapy, pre\u2010operative IDA management is feasible and results in a significant pre\u2010operative Hb increase compared to patients not treated. On the day of surgery 25% patients treated pre\u2010operatively were no longer anaemic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14495","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:15:36Z","timestamp":1720656936000},"page":"1338-1346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of a pre\u2010operative anaemia clinic in patients undergoing elective abdominal cancer surgery"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6818-4325","authenticated-orcid":false,"given":"Kristine Elisabeth Bagge","family":"Barsballe","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Centre for Cancer and Organ Diseases, Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Bundgaard\u2010Nielsen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Centre for Cancer and Organ Diseases, Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte","family":"Ruhnau","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Centre for Cancer and Organ Diseases, Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Georg","family":"Hillings\u00f8e","sequence":"additional","affiliation":[{"name":"Department of Surgery and Transplantation Centre for Cancer and Organ Diseases, Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eske Kvanner","family":"Aasvang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Centre for Cancer and Organ Diseases, Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8ivind","family":"Jans","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Centre for Cancer and Organ Diseases, Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)31539\u20107"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9861"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001646"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496965"},{"key":"e_1_2_10_6_1","first-page":"117","volume-title":"Blood Transfusion NICE Guideline [NG24]","author":"2020 Surveillance of Blood Transfusion","year":"2015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2450\/2021.0058\u201021"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13840"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13773"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10328"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14659"},{"key":"e_1_2_10_12_1","unstructured":"Checklists \u2010 STROBE. 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