{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:43:50Z","timestamp":1787510630555,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This Intensive Care Medicine Rapid Practice Guideline (ICM\u2010RPG) provides an evidence\u2010based recommendation to address the question: in adult patients in intensive care units (ICUs), should we use small\u2010volume or conventional blood collection tubes?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 23 panelists in 8 countries and assessed and managed financial and intellectual conflicts of interest. Methodological support was provided by the Guidelines in Intensive Care, Development, and Evaluation (GUIDE) group. We conducted a systematic review, including evidence from observational and randomized studies. Using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach, we evaluated the certainty of evidence and developed recommendations using the Evidence\u2010to\u2010Decision framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 8 studies (1 cluster and 2 patient\u2010level randomized trials; 5 observational studies) comparing small\u2010volume to conventional tubes. We had high certainty evidence that small\u2010volume tubes reduce daily and cumulative blood sampling volume; and moderate certainty evidence that they reduce the risk of transfusion and mean number of red blood cell units transfused, but these estimates were limited by imprecision. We had high certainty that small\u2010volume tubes have a similar rate of specimens with insufficient quantity. The panel considered that the desirable effects of small\u2010volume tubes outweigh the undesirable effects, are less wasteful of resources, and are feasible, as demonstrated by successful implementation across multiple countries, although there are upfront implementation costs to validate small\u2010volume tubes on laboratory instrumentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This ICM\u2010RPG panel made a strong recommendation for the use of small\u2010volume sample collection tubes in adult ICUs based on overall moderate certainty evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.14497","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T02:09:05Z","timestamp":1721614145000},"page":"1319-1326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Small\u2010volume blood sample collection tubes in adult\n                    <scp>intensive care units<\/scp>\n                    : A rapid practice guideline"],"prefix":"10.1111","volume":"68","author":[{"given":"Jeannie","family":"Callum","sequence":"first","affiliation":[{"name":"Pathology and Molecular Medicine Queen's University and Kingston Health Sciences Centre  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1740-4322","authenticated-orcid":false,"given":"Zbignew","family":"Putowski","sequence":"additional","affiliation":[{"name":"Center for Intensive Care and Perioperative Medicine Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Alhazzani","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University  Hamilton Ontario Canada"},{"name":"Department of Critical Care, College of Medicine King Saud University  Riyadh Saudi Arabia"},{"name":"Research Institute of St. Joseph's Healthcare Hamilton  Hamilton Ontario Canada"},{"name":"GUIDE Group  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Belley\u2010Cote","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University  Hamilton Ontario Canada"},{"name":"GUIDE Group  Hamilton Ontario Canada"},{"name":"Population Health Research Institute  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Hylander","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"GUIDE Group  Hamilton Ontario Canada"},{"name":"Department of Intensive Care Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Curry","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology, Haemophilia &amp; 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