{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:27:17Z","timestamp":1791433637185,"version":"4.3.3"},"reference-count":112,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The anterior quadratus lumborum (QL) block may be used for postoperative pain management for intra\u2010abdominal surgeries, but the evidence is uncertain. We aimed to investigate the benefit and harm of the anterior QL block compared to placebo\/no block for intra\u2010abdominal surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched Medline, Embase, and CENTRAL for randomized controlled trials investigating anterior QL block for postoperative pain management for adult patients undergoing any intra\u2010abdominal surgery. The two co\u2010primary outcomes were cumulative 24\u2010h opioid consumption and serious adverse events. We performed meta\u2010analysis, trial sequential analysis (TSA), assessed the risk of bias, and present the certainty of evidence with the Grading of Recommendations, Assessment, Development and Evaluation approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010five trials randomizing 2418 patients were included in the meta\u2010analyses. Anterior QL block may reduce cumulative 24\u2010h intravenous opioid consumption compared to placebo\/no block (MD \u221210.42\u2009mg, 96.7% CI \u221214.83 to \u22126.01, TSA\u2010adjusted CI \u221217.03 to \u22123.82,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01). Two trials reported on SAEs. Anterior QL block may have little to no effect on the number of serious adverse events compared to placebo (RR 1.49, 96.7% CI 0.19 to 11.47,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.68), but the evidence is very uncertain. All trial results were assessed as being high risk of bias.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The anterior QL block may reduce cumulative 24\u2010h opioid consumption. Reported serious adverse events were few and the anterior QL block may have little to no effect on the number of SAEs, but the evidence was very uncertain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.14526","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T03:04:40Z","timestamp":1729220680000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Anterior quadratus lumborum blocks for postoperative pain treatment following intra\u2010abdominal surgery: A systematic review with meta\u2010analyses and trial sequential analyses"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8086-5757","authenticated-orcid":false,"given":"Katrine","family":"Tanggaard","sequence":"first","affiliation":[{"name":"Centre for Anaesthesiological Research, Department of Anesthesiology and Intensive Care Medicine Zealand University Hospital  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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper D.","family":"Tvarn\u00f8","sequence":"additional","affiliation":[{"name":"Centre for Anaesthesiological Research, Department of Anesthesiology and Intensive Care Medicine Zealand University Hospital  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9839-3812","authenticated-orcid":false,"given":"Jens","family":"B\u00f8rglum","sequence":"additional","affiliation":[{"name":"Centre for Anaesthesiological Research, Department of Anesthesiology and Intensive Care Medicine Zealand University Hospital  Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9037-7295","authenticated-orcid":false,"given":"Mathias","family":"Maagaard","sequence":"additional","affiliation":[{"name":"Centre for Anaesthesiological Research, 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