{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T23:52:03Z","timestamp":1781221923605,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Haemorrhage is a leading cause of morbidity and mortality in trauma, and prehospital transfusion of blood products is often necessary. Whole blood has been proposed to be the best alternative, but it is unclear whether, and how, storage and transport of the blood in a helicopter affects the blood units. We investigated the coagulation capacity and platelet function in whole blood at different time points during helicopter missions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty units of low\u2010titre group O RhD negative whole blood were collected from healthy volunteers and analysed before, during and after transport in a helicopter. Coagulation and platelet function, as measured by thromboelastography, and blood samples for pH, electrolytes, glucose and lactate were assessed at baseline and 24, 72 and 168\u2009h after storage in the helicopter. Plasma concentrations of coagulation factors and haemoglobin and blood counts were measured at baseline and after 168\u2009h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma concentrations of coagulation factors and haemoglobin did not change during storage and transport. Platelet counts decreased from a baseline mean of 172\u2009\u00b1\u200929\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L to a mean of 120\u2009\u00b1\u200928\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L after 168\u2009h, and platelet function worsened slightly but significantly by 8%\u20139% during storage and transport. pH and glucose decreased while potassium and lactate levels increased after 168\u2009h compared with baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Storage and transport of whole\u2010blood units in a rescue helicopter, for up to 168\u2009h, had a slight impact on the blood quality. Storage of whole blood on board of the helicopter holds up to European standard, measured as temperature and haemolysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14568","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T06:45:32Z","timestamp":1737355532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Coagulation and platelet function in cold\u2010stored whole blood on missions in a helicopter emergency service"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8710-9142","authenticated-orcid":false,"given":"Jos\u00e9\u2010Gabriel","family":"Sato Folatre","sequence":"first","affiliation":[{"name":"Helicopter Emergency Medical Service Region V\u00e4stra G\u00f6taland  Kung\u00e4lv Sweden"},{"name":"Department of Anaesthesiology and Intensive Care, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8810-7974","authenticated-orcid":false,"given":"Agneta","family":"Wikman","sequence":"additional","affiliation":[{"name":"Centre for Haematology and Regenerative Medicine (HERM) Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Clinical Science, Intervention and Technology (CLINTEC) Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Radulovic","sequence":"additional","affiliation":[{"name":"Department of Haematology and Coagulation Disorders Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7352-4356","authenticated-orcid":false,"given":"G\u00f6ran","family":"Sandstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of War Studies Swedish Defence University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Skallsj\u00f6","sequence":"additional","affiliation":[{"name":"Helicopter Emergency Medical Service Region V\u00e4stra G\u00f6taland  Kung\u00e4lv Sweden"},{"name":"Department of Anaesthesiology and Intensive Care, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Arnell","sequence":"additional","affiliation":[{"name":"Helicopter Emergency Medical Service Region V\u00e4stra G\u00f6taland  Kung\u00e4lv Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1445-7525","authenticated-orcid":false,"given":"Sven\u2010Erik","family":"Ricksten","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8187-9760","authenticated-orcid":false,"given":"Birgitta","family":"Romlin","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Paediatric Anaesthesia and Intensive Care, Queen Silvia Children's Hospital, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1109343"},{"key":"e_1_2_12_3_1","unstructured":"SchyllanderJ LundqvistE TennlindA Stenb\u00e4ckI.Personskador i Sverige. Myndigheten f\u00f6r samh\u00e4llsskydd och beredskap (MSB).2012."},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04327-7"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14983"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181271ba3"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2022.6978"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000051"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001608"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06266-1"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15802"},{"key":"e_1_2_12_12_1","article-title":"Introduction of prehospital blood transfusion programme in Sweden: experiences from a physician staffed helicopter emergency medical service","volume":"115","author":"Sato Folatre J\u2010G","year":"2018","journal-title":"Lakartidningen"},{"key":"e_1_2_12_13_1","article-title":"Blood components, special components and whole blood\u2014what and to whom?","volume":"118","author":"Wikman A","year":"2021","journal-title":"Lakartidningen"},{"key":"e_1_2_12_14_1","unstructured":"BjerkvigC.Whole blood in prehospital damage control resuscitation\u2014safety feasibility and logistics. Department of Anesthesia and Intensive Care. University of Bergen.2023."},{"key":"e_1_2_12_15_1","unstructured":"UnionE.Guide to the preparation use and quality assurance of blood components 20th Edition."},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2019.1704713"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26285"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23599"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/POC.0000000000000036"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182755dcc"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.15097"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1802345"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(22)00040-0"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3180324124"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17012"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13441"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/tsaco-2022-001052"},{"key":"e_1_2_12_28_1","first-page":"506","article-title":"Is low\u2010titer group O whole blood truly a universal blood product?","volume":"236","author":"Brill JB","year":"2022","journal-title":"J Am Coll Surg"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/XCS.0000000000000086"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005603"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2020.09.007"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15159"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01253-9"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15669"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000082"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002799"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13005"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001535"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37397240207.x"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1983.23584018713.x"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001646"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-7963(03)00022-1"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02772.x"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2011.09.005"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.14568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T12:57:37Z","timestamp":1737377857000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.14568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,19]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/aas.14568"],"URL":"https:\/\/doi.org\/10.1111\/aas.14568","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,19]]},"assertion":[{"value":"2024-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14568"}}