{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:32:07Z","timestamp":1793298727732,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T00:00:00Z","timestamp":1744502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fever is associated with brain injury after cardiac arrest. It is unknown whether fever management with a feedback\u2010controlled device impacts patient\u2010centered outcomes in cardiac arrest patients. This trial aims to investigate fever management with or without a temperature control device after out\u2010of\u2010hospital cardiac arrest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The TEMP\u2010CARE trial is part of the 2\u2009\u00d7\u20092\u2009\u00d7\u20092 factorial <jats:italic>Sedation, TEmperature and Pressure after Cardiac Arrest and REsuscitation (STEPCARE)<\/jats:italic> trial, a randomized, international, multicenter, parallel\u2010group, investigator\u2010initiated, superiority trial that will evaluate sedation strategies, temperature management, and blood pressure targets simultaneously in nontraumatic\/nonhemorrhagic out\u2010of\u2010hospital cardiac arrest patients following hospital admission. For the temperature management component of the trial described in this protocol, patients will be randomly allocated to fever management with or without a feedback\u2010controlled temperature control device. For those managed with a device, if temperature \u226537.8\u00b0C occurs within 72\u2009h post\u2010randomization the device will be started targeting a temperature of \u226437.5\u00b0C. Standard fever treatment, as recommended by local guidelines, including pharmacological agents, will be provided to participants in both groups. The two other components of the STEPCARE trial evaluate sedation and blood pressure strategies. Apart from the STEPCARE trial interventions, all other aspects of general intensive care will be according to the local practices of the participating site. A physician blinded to the intervention will determine the neurological prognosis following European Resuscitation Council and European Society of Intensive Care Medicine guidelines. The primary outcome is all\u2010cause mortality at six months post\u2010randomization. To detect a 5.6% absolute risk reduction (90% power, alpha .05), 3500 participants will be enrolled. Secondary outcomes include poor functional outcome at six months, intensive care\u2010related serious adverse events, and overall health status at six months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The TEMP\u2010CARE trial will investigate if post\u2010cardiac arrest management of fever with or without a temperature control device affects patient\u2010important outcomes after cardiac arrest.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.70034","type":"journal-article","created":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T23:22:51Z","timestamp":1744586571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Fever management with or without a temperature control device after out\u2010of\u2010hospital cardiac arrest and resuscitation (<scp>TEMP<\/scp>\u2010<scp>CARE<\/scp>): A study protocol for a randomized clinical trial"],"prefix":"10.1111","volume":"69","author":[{"given":"Johan","family":"Holgersson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund, Anesthesia and Intensive Care Lund University  Lund Sweden"},{"name":"Department of Anesthesia and Intensive Care Helsingborg Hospital  Helsingborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5048-4801","authenticated-orcid":false,"given":"V.","family":"Niemel\u00e4","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0341-0262","authenticated-orcid":false,"given":"M. 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