{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:28:46Z","timestamp":1783394926928,"version":"3.54.6"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Patients undergoing spine surgery often experience post\u2010operative pain. In this context, clonidine, an alpha\u20102 agonist, may be relevant due to its analgesic properties. We conducted a randomised, double\u2010blinded, placebo\u2010controlled trial to evaluate the effect of a single dose of intraoperative intravenous clonidine on post\u2010operative opioid consumption, pain intensity and side effects. Patients undergoing spine surgery at Aarhus University Hospital, Denmark, were randomised to receive intraoperative clonidine (3\u2009\u03bcg\/kg) or placebo. The primary outcome was opioid consumption within the first 3\u2009h after surgery. Secondary outcomes included opioid consumption within the first 6\u2009h, pain intensity at rest and during coughing, post\u2010operative nausea and vomiting (PONV), and sedation in the post\u2010anaesthesia care unit (PACU). Additional outcomes included time to discharge from the PACU, length of hospital stay and daily opioid consumption after 1\u2009month. Data from 120 patients (49 females, 71 males, mean age 65\u2009\u00b1\u200914\u2009years) were available for analysis; 61 received clonidine and 59 received placebo. Post\u2010operative intravenous morphine equivalents within 3\u2009h were similar in the clonidine group 5\u2009mg (0\u201315) and the placebo group 10\u2009mg (0\u201315) (<jats:italic>p<\/jats:italic>\u2009=\u20090.58). Pain intensity at rest was 4 (0\u20135.5) in the clonidine group and 3 (0\u20135) in the placebo group upon arrival at the PACU (<jats:italic>p<\/jats:italic>\u2009=\u20090.20). No differences were observed between the clonidine and placebo groups regarding any secondary outcomes, except for hypotension, which was more frequent in the clonidine group (24 vs. 13 patients). A single dose of intraoperative clonidine did not reduce post\u2010operative opioid consumption or pain intensity in patients undergoing spine surgery.<\/jats:p>","DOI":"10.1111\/aas.70048","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:16:50Z","timestamp":1748351810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intraoperative Clonidine in Spine Surgery: A Randomised Controlled Trial"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0770-1726","authenticated-orcid":false,"given":"Stine","family":"Birkeb\u00e6k","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Juul","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel Mylius","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Neurosurgery Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2560-1705","authenticated-orcid":false,"given":"Peter Gaarsdal","family":"Uhrbrand","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"Nikolajsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Anaesthesiology and Intensive Care Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2021-102583"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.09.20"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68700-X"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000809"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000004039"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujps.2011.08.045"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30428-3"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2017.02.003"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(85)90537-4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970\u20109185.74581"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00609752"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03008314"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542\u2010199110000\u201000006"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/1053\u20100770(92)90156\u20102"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5049.100817"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/eujp.2001.0270"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/1658-354X.144078"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0218492316663359"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/11101849.2022.2031546"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5152\/TJAR.2020.55938"},{"issue":"1","key":"e_1_2_10_22_1","first-page":"135","article-title":"Comparison Between Intravenous and Intrathecal Clonidine for Postoperative Analgesia of Patients Submitted to Laparoscopic Cholecystectomy: Randomized Clinical Trial","volume":"72","author":"Silva C. 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