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Recent evidence shows that non\u2010resuscitation fluids are the major modifiable source of fluids for patients with septic shock in intensive care units (ICUs). This clinical trial is designed to test the hypothesis that restrictive administration of non\u2010resuscitation fluids improves outcomes compared to usual care. Adult patients admitted to ICUs with septic shock will be randomly assigned within 12\u2009h of admission to receive protocolized restrictive administration of non\u2010resuscitation fluids or usual care. The primary outcome is all\u2010cause mortality at 90\u2009days. Secondary outcomes are complications during ICU stay up to 90\u2009days (defined as any acute kidney injury or cerebral, coronary, intestinal, or limb ischemia), mechanical ventilation free days within 90\u2009days, and for survivors cognitive function (by the Montreal Cognitive Assessment [MOCA\u2010BLIND]) and Health\u2010Related Quality of Life (by the EQ Visual Analogue Scale [EQ\u2010VAS]), both at 6\u2009months. In addition, the climate impact of the interventions will be assessed. To detect an absolute reduction in mortality of 7.5%, with an alpha of 5% and a power of 90%, we aim to include 1850 patients. The trial is approved by the Swedish Ethical Review Authority. Results of primary and secondary clinical outcomes and the environmental outcome will be submitted for publication in a peer\u2010reviewed journal.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> NCT06140147.<\/jats:p>","DOI":"10.1111\/aas.70095","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T05:14:27Z","timestamp":1752729267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Protocolized <scp>REDUction<\/scp> of Non\u2010Resuscitation Fluids in <scp>SEptic<\/scp> Shock Patients. 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