{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:39:13Z","timestamp":1787240353046,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004257","name":"Helse Vest","doi-asserted-by":"publisher","award":["200 000 NOK"],"award-info":[{"award-number":["200 000 NOK"]}],"id":[{"id":"10.13039\/501100004257","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Characteristics and outcomes of patients with acute pancreatitis (AP) admitted to intensive care units (ICUs) are not well described in complete population\u2010based national cohorts. Thus, we aimed to investigate the incidence over time and predictors of short\u2010 and long\u2010term survival of AP treated in ICUs in a national cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nationwide observational cohort study in a universal healthcare system. Adult patients with AP admitted to Norwegian ICUs from 2016 to 2021 were identified using coded data from the Norwegian Intensive Care and Pandemic Registry and the Norwegian Patient Registry. Logistic regression was used to identify predictors of 90\u2010day mortality. Overall survival was analyzed using Cox regression, and post\u2010discharge survival was assessed for conditional relative survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1183 patients were identified, with a median age of 64.8\u2009years (interquartile range [IQR] 52.0\u201375.3) and 60.4% men. The average annual incidence was 3.8 per 100,000 inhabitants and increased significantly (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>trend<\/jats:sub>\n                      \u2009=\u20090.048) during the study period. In\u2010hospital mortality was 20.5% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009243), 90\u2010day mortality 22.8% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009270), and the overall 1\u2010year cumulative mortality was 28.0% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009331). Independent predictors of 90\u2010day mortality included age (OR 1.05; 95% CI 1.04\u20131.07), SAPS II score (OR 1.06; 95% CI 1.05\u20131.07), Charlson Comorbidity Index (CCI) score (OR 1.2; 95% CI 1.10\u20131.31), and pancreatitis etiology. In the multivariable survival analysis of hospital survivors, age (HR 1.05; 95% CI 1.04\u20131.07), SAPS II (HR 1.01; 95% CI 1.00\u20131.02), and CCI (HR 1.29; 95% CI 1.21\u20131.38) were associated with increased risk of death, whereas biliary etiology (HR 0.48; 95% CI 0.30\u20130.78) and longer ICU length of stay (HR 0.98; 95% CI 0.97\u20131.00) were associated with a reduced risk of death. No association was found between advanced organ support and the risk of death after discharge from the hospital. Compared to an age\u2010 and gender\u2010matched population, long\u2010term survival of patients discharged alive was approximately 90%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Admissions to the ICU for AP seem to increase in a national cohort, and 90\u2010day mortality occurred in almost every 1 of 4 patients. Patients with ICU\u2010treated AP discharged alive from the hospital have good long\u2010term survival, although with reduced longevity compared to the age\u2010 and gender\u2010adjusted general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Editorial Comment<\/jats:title>\n                    <jats:p>This registry\u2010based nationwide study assesses the incidence and short\u2010 and long\u2010term outcomes of AP in Norwegian ICUs over a 6\u2010year period. The incidence of intensive care\u2010treated pancreatitis seems to be increasing over this time period. Long\u2010term outcome for the hospital survivors is good, almost at the level of the general population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.70164","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T13:54:24Z","timestamp":1765374864000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Incidence, Mortality, and Long\u2010Term Survival in Patients With Acute Pancreatitis Admitted to Intensive Care: A Nationwide Cohort Study"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2302-8019","authenticated-orcid":false,"given":"Jannicke Horjen","family":"M\u00f8ller","sequence":"first","affiliation":[{"name":"Department of Intensive Care Stavanger University Hospital  Stavanger Norway"},{"name":"Department of Clinical Medicine University of Bergen  Bergen 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