{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:51:43Z","timestamp":1779893503472,"version":"3.53.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Emergence delirium (ED) and emergence agitation (EA) are behavioural disturbances in the early postoperative period in children. Preschool\u2010aged children (1\u20136\u2009years) undergoing adeno\u2010tonsillectomy constitute a high\u2010risk group. The \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    \u2010adrenergic agonist dexmedetomidine has emerged as a potential preventive\/therapeutic agent for ED\/EA, but evidence in this specific subgroup is fragmented. To map and characterise the body of evidence regarding dexmedetomidine use for preventing or managing ED\/EA in preschool children undergoing adeno\u2010tonsillectomy. A scoping review will be conducted in accordance with JBI methodology and reported via the PRISMA\u2010ScR checklist. Searches will be performed in MEDLINE, Embase, CINAHL, CENTRAL, and grey literature. Eligible studies will include preschool (1\u20136\u2009years) children undergoing adeno\u2010tonsillectomy where dexmedetomidine was used perioperatively. Two reviewers will screen and extract data independently. Data will be charted on dexmedetomidine dosing, routes, timing, outcome definitions, effects on ED\/EA, secondary outcomes, and adverse events. A descriptive synthesis will identify evidence patterns and gaps. This review will provide the first consolidated overview of dexmedetomidine use specifically in preschool children undergoing adeno\u2010tonsillectomy for ED\/EA prevention or management. The findings may inform clinical practice and guide future targeted trials.\n                  <\/jats:p>","DOI":"10.1111\/aas.70183","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T06:58:25Z","timestamp":1768373905000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dexmedetomidine for Emergence Delirium and Agitation in Preschool Children Undergoing Adeno\u2010Tonsillectomy: A Scoping Review Protocol"],"prefix":"10.1111","volume":"70","author":[{"given":"Simon","family":"Hanssen","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Akershus University Hospital  L\u00f8renskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Ali Abdul\u2010Mahdi","family":"Hadi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Akershus University Hospital  L\u00f8renskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Haidl","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Akershus University Hospital  L\u00f8renskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5896-9768","authenticated-orcid":false,"given":"Tom G.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Akershus University Hospital  L\u00f8renskog Norway"},{"name":"Institute of Clinical Medicine Oslo University  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew477"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjae.2017.07.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4097\/kja.20097"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200405000-00015"},{"key":"e_1_2_8_6_1","first-page":"174","article-title":"Emergence Agitation in Children: A Review","volume":"13","author":"Voepel\u2010Lewis T.","year":"2003","journal-title":"Paediatric Anaesthesia"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1465999"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e31822b8629"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/children12060690"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjae.2020.05.004"},{"key":"e_1_2_8_12_1","first-page":"320","article-title":"Dexmedetomidine in the Pediatric Population: A Review","volume":"81","author":"Plambech M. Z.","year":"2015","journal-title":"Minerva Anestesiologica"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005566"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.46658\/JBIMES-24-09"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012058"},{"key":"e_1_2_8_17_1","first-page":"685","article-title":"Pharmacological Prevention of Sevoflurane\u2010Related Emergence Agitation in Children: A Systematic Review and Meta\u2010Analysis","volume":"31","author":"Dahmani S.","year":"2014","journal-title":"European Journal of Anaesthesiology"},{"key":"e_1_2_8_18_1","first-page":"555","article-title":"Emergence Delirium or Pain After Anaesthesia\u2014How to Distinguish Between the Two in Young Children: A Retrospective Analysis","volume":"26","author":"Somaini M.","year":"2016","journal-title":"Paediatric Anaesthesia"},{"key":"e_1_2_8_19_1","first-page":"662","article-title":"The Pediatric Anesthesia Emergence Delirium (PAED) Scale: A Systematic Review and Meta\u2010Analysis of Its Psychometric Properties","volume":"25","author":"Somaini M.","year":"2015","journal-title":"Paediatric Anaesthesia"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-016-0201-5"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.70183","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aas.70183","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.70183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:16:05Z","timestamp":1771046165000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.70183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,13]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/aas.70183"],"URL":"https:\/\/doi.org\/10.1111\/aas.70183","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,13]]},"assertion":[{"value":"2025-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70183"}}