{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:04:05Z","timestamp":1771049045203,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008269","name":"L\u00e6ge Sofus Carl Emil Friis og Hustru Olga Doris Friis' Legat","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intraoperative hypotension is a well\u2010known clinical condition and often treated with vasoactive agents. Previous cohort studies have indicated that large numbers of patients receive this treatment, but they have been limited to specific surgical populations or single agents. Furthermore, it is unknown which agents are the most frequently used and whether certain patient factors make intraoperative vasoactive treatment more likely. With this study, we aim to describe the proportion of patients receiving intraoperative vasoactive agents and the choice of agent; to highlight patient characteristics associated with the need for treatment and, finally, to describe prevalences of postoperative complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Outcomes<\/jats:title>\n                    <jats:p>We will conduct a secondary study of the international cohort study \u2018Vasopressor use after non\u2010cardiac surgery: an international observational study (SQUEEZE)', specifically focusing on intraoperative data from approximately 19,000 adult patients undergoing non\u2010cardiac, non\u2010obstetric, non\u2010transplant surgery as in\u2010patients. Data were collected at each participating site during one consecutive week between October 2020 and October 2023. The primary outcome is the proportion of patients who received intraoperative vasoactive treatment. The secondary outcomes are the proportion of patients receiving each one of the pre\u2010specified agents and the proportion of patients experiencing pre\u2010specified postoperative complications including death and hospital length of stay. We will descriptively present data on the prevalence of intraoperative use of vasoactive agents, the choice of agents, and postoperative complications. We will conduct logistic regression analyses to assess possible associations between baseline variables and use of intraoperative vasoactive therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The outlined study will provide valuable epidemiological data on the intraoperative use of vasoactive agents in adult patients undergoing non\u2010cardiac, non\u2010obstetric, non\u2010transplant surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.70188","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:24:31Z","timestamp":1768451071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intraoperative Use of Vasoactive Agents in Non\u2010Cardiac Surgery: Protocol for a Post Hoc Cohort Study"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1281-8243","authenticated-orcid":false,"given":"Emilie Stokholm","family":"B\u00e6kgaard","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Holb\u00e6k Hospital  Holb\u00e6k Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Vester\u2010Andersen","sequence":"additional","affiliation":[{"name":"Herlev Anaesthesia Critical and Emergency Care Science Unit Copenhagen University Hospital \u2010 Herlev\u2010Gentofte  Herlev Denmark"},{"name":"Department of Anaesthesia and Intensive Care, Copenhagen University Hospital \u2010 Herlev\u2010Gentofte University of Copenhagen  Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5799-7655","authenticated-orcid":false,"given":"Anders","family":"Granholm","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"},{"name":"Section of Biostatistics, Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6378-9673","authenticated-orcid":false,"given":"Morten Hylander","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Creagh\u2010Brown","sequence":"additional","affiliation":[{"name":"SQUEEZE Steering Committee European Society for Anaesthesia and Intensive Care (ESAIC)  Brussels Belgium"},{"name":"Intensive Care Unit Royal Surrey County Hospital  Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ib","family":"Jammer","sequence":"additional","affiliation":[{"name":"SQUEEZE Steering Committee European Society for Anaesthesia and Intensive Care (ESAIC)  Brussels Belgium"},{"name":"Department of Anaesthesia and Intensive Care Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"Krag","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Anaesthesiology, Surgery and Trauma Centre Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.04.036"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005250"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.01.013"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002295"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2023.101224"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004774"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2025.07.034"},{"key":"e_1_2_12_9_1","unstructured":"\u201cPaper CRF [Internet] \u201dSQUEEZE Int. 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Study Doc. cited September 25 2024 https:\/\/esaic.org\/wp\u2010content\/uploads\/2023\/12\/squeeze\u2010paper\u2010crf\u2010v3\u20100_final_22jan21.pdf."},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.050051"},{"key":"e_1_2_12_11_1","unstructured":"\u201cClinical Frailty Scale [Internet] \u201dDalhouse University cited May 28 2025 https:\/\/www.dal.ca\/sites\/gmr\/our\u2010tools\/clinical\u2010frailty\u2010scale.html."},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/26.4.404"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.31523\/glmj.047002.002"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.11.024"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-017-0442-1"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2393"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_12_18_1","unstructured":"ICMJE \u201cRecommendations | Defining the Role of Authors and Contributors [Internet] \u201dcited February 7 2025 https:\/\/www.icmje.org\/recommendations\/browse\/roles\u2010and\u2010responsibilities\/defining\u2010the\u2010role\u2010of\u2010authors\u2010and\u2010contributors.html."}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.70188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aas.70188","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.70188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:15:54Z","timestamp":1771046154000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.70188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/aas.70188"],"URL":"https:\/\/doi.org\/10.1111\/aas.70188","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,14]]},"assertion":[{"value":"2025-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70188"}}