{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:52:22Z","timestamp":1789563142563,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment\u2010limiting decisions (TLDs) in neurointensive care are frequently reported with no distinction between withholding and withdrawal of treatment. We investigated the proportion of patients subjected to withholding and withdrawal of life\u2010sustaining treatment during neurointensive care, and the association with mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational cohort study included all adult (\u2265\u200918\u2009years) neurocritically ill patients admitted to the neurointensive care unit (neuro\u2010ICU), Rigshospitalet, Denmark, for a primary CNS injury during the period from July 2019 to February 2022. Patients were categorised into the following three groups: full treatment, withholding, or withdrawal of life\u2010sustaining treatment. We compared 30\u2010day all\u2010cause mortality of the three groups by a Cox proportional\u2010hazards model and by calculating the mean restricted survival time at 30\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 694 eligible patients, a decision to withhold or withdraw treatment was made for 50 (7.2%) and 124 (17.9%) patients, respectively. Patients subjected to withholding were older and had a higher Charlson Comorbidity Index, whereas those subjected to withdrawal had a lower Glasgow Coma Score (GCS) and a higher Acute Physiology and Chronic Health Evaluation II score. While the primary neurological injury was the main reason for the treatment\u2010limiting decision, and comorbidity contributed in both groups, a history of cardiac arrest was also stated as a reason for withdrawing, and non\u2010neurological injury as a reason for withholding therapy. The 30\u2010day case fatality ratio was 32%, 98% and 8.1% for patients subjected to withholding, withdrawal and full treatment, respectively, corresponding to a mean restricted survival time at 30\u2009days of 24 (95% CI, 21\u201327), 10.0 (8.2\u201312) and 29 (28, 29) days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, TLDs were made in one out of four neuro\u2010ICU patients. Furthermore, neurocritically ill patients subjected to withholding treatment had markedly higher survival than those subjected to withdrawal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Editorial Comment<\/jats:title>\n                    <jats:p>In this assessment of treatment\u2010limiting decisions in neuro\u2010intensive care cases, the authors present how withholding escalating ICU treatment can occur in case conditions that differ from those where active ICU treatment is withdrawn.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.70202","type":"journal-article","created":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T23:00:32Z","timestamp":1771801232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Treatment\u2010Limiting Decisions in Neurointensive Care: Withholding or Withdrawal of Life\u2010Sustaining Measures"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1115-6260","authenticated-orcid":false,"given":"Isabella Carvalho","family":"Ankerstjerne","sequence":"first","affiliation":[{"name":"Department of Neuroanaesthesiology The Neuroscience Centre, Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6423-4549","authenticated-orcid":false,"given":"Anne\u2010Sophie Worm","family":"Fenger","sequence":"additional","affiliation":[{"name":"Department of Neuroanaesthesiology The Neuroscience Centre, Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0981-0723","authenticated-orcid":false,"given":"Markus Harboe","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Neuroanaesthesiology The Neuroscience Centre, Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ove","family":"Bergdal","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Neuroscience Centre, Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kondziella","sequence":"additional","affiliation":[{"name":"Department of Neurology The Neuroscience Centre, Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene Ravnholt","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Neuroanaesthesiology The Neuroscience Centre, Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8042-3262","authenticated-orcid":false,"given":"Gorm","family":"Greisen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Neonatology The Neuroscience Centre, Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9463-1919","authenticated-orcid":false,"given":"Tiit Illimar","family":"Mathiesen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Neuroscience Centre, Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Neuroscience Karolinska Instituttet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3058-1072","authenticated-orcid":false,"given":"Kirsten","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Neuroanaesthesiology The Neuroscience Centre, Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-015-0137-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003647"},{"key":"e_1_2_10_4_1","first-page":"1","article-title":"Clinical Nihilism in Neuro\u2010Emergencies","volume":"23","author":"Hemphill J. 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