{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:19:45Z","timestamp":1787908785241,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002918","name":"Gentofte Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002918","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinicians often administer opioids to manage postoperative pain, but with considerable variation in chosen opioid and dosing strategies. This post hoc analysis of a Danish nationwide survey assessed how profession, length of experience, and geographical region impact dosing in the intraoperative phase (end of surgery) and the postoperative phase (PACU) for postoperative control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 37\u2010item online survey on opioid practice amongst anaesthesia personnel in Denmark (5 February\u201330 April 2024). Regression analyses compared intravenous morphine equivalent doses (MEQ) in eight clinical cases for three provider characteristics: profession (physician\/nurse), length of experience (&gt;\u2009&lt;\u200910\u2009years) and geographical region (five regions). We predefined differences \u2265\u20090.03\u2009mg\/kg MEQ as clinically relevant. We qualitatively described group differences in perioperative factors guiding dose adjustments, defining differences \u2265\u200910% as relevant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The overall response rate was 48% (2025\/4187). In four intraoperative clinical cases, anaesthesiologists administered on average 0.04\u2009mg\/kg MEQ less than nurse anaesthetists (95% CI: 0.03 to 0.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), considered clinically relevant. Respondents with short working experience (&lt;\u200910\u2009years) administered 0.01\u2009mg\/kg MEQ less (95% CI: 0.00 to 0.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Respondents in the North Denmark Region administered 0.07\u2009mg\/kg MEQ more than the national average of 0.32\u2009mg\/kg MEQ (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), considered clinically relevant. In postoperative clinical cases, significant dosing differences between short versus long working experience were not considered clinically relevant. Clinically relevant differences in dose\u2010adjusting factors existed between professions (preoperative opioid use, age, body weight, alcohol use, chronic pain, and ASA classification) and regions (chronic pain, body weight, preoperative opioid use, ASA classification, sedation, BMI, and nausea).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clinical profession and regional background contribute to variation in opioid dosing strategies. Nurse anaesthetists and respondents from the North Denmark Region administered significantly and clinically relevant higher doses of opioids. Clinically relevant differences existed between professions and regions regarding opioid dose\u2010adjusting factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Editorial Comment<\/jats:title>\n                    <jats:p>This secondary analysis of survey results from Denmark regarding opioid choices and dosing preferences for post\u2010surgical analgesia focused on professional categories and regions within Denmark. Some apparent dosing preference differences were described between professional groups and also between regions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.70222","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T08:30:42Z","timestamp":1775118642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Influence of Profession, Experience and Geographical Region on Intra\u2010 and Postoperative Opioid Practice in Denmark: A Post Hoc Analysis of the\n                    <scp>OPIAID<\/scp>\n                    Survey"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8491-3389","authenticated-orcid":false,"given":"Trang Xuan Minh","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mik","family":"Wetterslev","sequence":"additional","affiliation":[{"name":"Department of Intensive Care 4131 Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6908-7832","authenticated-orcid":false,"given":"Anders Kehlet","family":"N\u00f8rskov","sequence":"additional","affiliation":[{"name":"Centre for Anaesthesiological Research, Department of Anesthesiology Zealand University Hospital  K\u00f8ge Denmark"},{"name":"Department of Anaesthesiology Copenhagen University Hospital \u2013 North Zealand  Hiller\u00f8d Denmark"},{"name":"Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4885-4609","authenticated-orcid":false,"given":"Christian S.","family":"Meyhoff","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0981-0723","authenticated-orcid":false,"given":"Markus Harboe","family":"Olsen","sequence":"additional","affiliation":[{"name":"Centre for Anaesthesiological Research, Department of Anesthesiology Zealand University Hospital  K\u00f8ge Denmark"},{"name":"Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region of Denmark, Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of 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