{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:58:23Z","timestamp":1785376703226,"version":"3.55.0"},"reference-count":7,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n This study investigates long\u2010term survival in the Cancer and Anaesthesia (CAN) study, focusing on the potential impact of local anaesthetic infiltration during breast cancer surgery. A positive effect from peritumoral infiltration has recently been suggested. We conducted an exploratory data analysis to examine a possible association between uncontrolled exposure to local anaesthetics during breast cancer surgery and long\u2010term survival.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Breast cancer patients were recruited to compare long\u2010term survival according to whether anaesthesia was maintained with inhaled sevoflurane or intravenous propofol. Other aspects of anaesthesia, such as the use of local\u2010 or regional anaesthesia, were carried out pragmatically according to local institutional guidelines. Kaplan\u2013Meier survival curves were constructed to compare survival between those who received local anaesthetics or not.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 1670 analysed patients, 803 (48.1%) received local anaesthetic infiltration, 67 (4.0%) received a paravertebral block, 75 (4.5%) received both, and 725 (43.4%) received neither. Over a median follow\u2010up of 76.8\u2009months, no significant differences in overall survival were observed \u2013 either between the pooled group of patients who received any local or regional anaesthesia (\n n<\/jats:italic>\n \u2009=\u2009945) and those who received neither (\n n<\/jats:italic>\n \u2009=\u2009725;\n p<\/jats:italic>\n \u2009=\u20090.54), or among all four groups (\n p<\/jats:italic>\n \u2009=\u20090.89).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n We found no association with local\u2010anaesthetic skin infiltration or regional anaesthesia and long\u2010term survival in this non\u2010preplanned secondary analysis of a randomised controlled trial.<\/jats:p>\n <\/jats:sec>\n \n Editorial Comment<\/jats:title>\n In this secondary analysis of an observational follow\u2010up study for anaesthetic exposure and cancer outcomes, regional or localized local anaesthetic treatments were not associated with a survival advantage. How regional anaesthesia or local anaesthetics might interact with clinical cancer natural history in patients is still not clear, though the results here do not support a large effect.<\/jats:p>\n \n Trial Registration<\/jats:bold>\n : EudraCT number: 2013\u2010002380\u201025;\n ClinicalTrials.gov<\/jats:ext-link>\n Identifier: NCT01975064\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aas.70268","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T06:50:03Z","timestamp":1780037403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Secondary Analysis of the\n CAN<\/scp>\n \u2010Study, a Randomised Controlled Trial \u2013 Local Anaesthesia and Overall Survival"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9911-3029","authenticated-orcid":false,"given":"Mats","family":"Enlund","sequence":"first","affiliation":[{"name":"Center for Clinical Research V\u00e4stmanland Hospital V\u00e4ster\u00e5s, University of Uppsala Sweden"},{"name":"Department of Anaesthesia & Intensive Care V\u00e4stmanlands Sjukhus V\u00e4ster\u00e5s Sweden"},{"name":"Department of Surgical Sciences Uppsala University Uppsala Sweden"},{"name":"European Society of Anaesthesiology and Intensive Care Onco Anaesthesiology Research Group, EuroPeriscope Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Berglund","sequence":"additional","affiliation":[{"name":"Epistat AB Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8054-8847","authenticated-orcid":false,"given":"Leif","family":"Bergkvist","sequence":"additional","affiliation":[{"name":"Center for Clinical Research V\u00e4stmanland Hospital V\u00e4ster\u00e5s, University of Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the CAN\u2010Study\u2010Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.22.01966"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190705184218"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102037"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu201"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.07.015"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2017.12.043"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.12196"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.70268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aas.70268","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.70268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:13:52Z","timestamp":1785374032000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.70268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/aas.70268"],"URL":"https:\/\/doi.org\/10.1111\/aas.70268","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]},"assertion":[{"value":"2025-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70268"}}