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Although prolonged sedation has traditionally been considered necessary, contemporary normothermia\u2010based temperature control allows earlier wake\u2010up call. The optimal timing of an early wake\u2010up call remains unknown and may influence overall mortality, neurological recovery, duration of mechanical ventilation, and length of hospital stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Danish Out\u2010of\u2010Hospital Cardiac Arrest (DANOHCA) trial (clinicaltrials.gov identifier: NCT05895838; and euclinicaltrials.eu, identifier: 2024\u2013515,997\u201328\u201000) is an investigator\u2010initiated, multicenter, randomized clinical trial using a 2\u2009\u00d7\u20092\u2009\u00d7\u20092\u2009\u00d7\u20092 factorial design evaluating four interventions in patients resuscitated from OHCA. The present protocol describes the comparison of an early versus late wake\u2010up call strategy. Adult patients (\u2265\u200918\u2009years) with presumed cardiac\u2010cause of OHCA, sustained return of spontaneous circulation, and persistent unconsciousness on intensive care unit admission are randomized 1:1 to early wake\u2010up call (\u2264\u20096\u2009h after randomization) or late wake\u2010up call (28\u201336\u2009h after randomization). Wake\u2010up call includes interruption of sedation, assessment of neurology, and may be followed by extubation if predefined neurological and respiratory criteria are fulfilled. The primary endpoint is days alive and out of hospital within 30\u2009days after randomization. Analyses will follow a modified intention\u2010to\u2010treat principle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Perspectives<\/jats:title>\n                    <jats:p>Optimizing post\u2010resuscitation care remains a cornerstone in managing comatose cardiac arrest survivors and improving outcomes. We hypothesize that sedation for 28\u201336\u2009h leads to more days alive outside of the hospital in 30\u2009days compared to sedation for \u2264\u20096\u2009h.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      EudraCT number: 2016\u2010003265\u201026; EU CTIS no 2024\u2010515997\u201028\u201000;\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT05895838.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.70272","type":"journal-article","created":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T22:44:16Z","timestamp":1780872256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Versus Late Wake\u2010Up Call After Out\u2010Of\u2010Hospital Cardiac Arrest: Protocol for a Multicenter Randomized Comparison Within the Danish Out\u2010of\u2010Hospital Cardiac Arrest (\n                    <scp>DANOHCA<\/scp>\n                    ) Trial"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8850-2982","authenticated-orcid":false,"given":"Anders Morten","family":"Grejs","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5244-0399","authenticated-orcid":false,"given":"Jesper","family":"Kjaergaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital\u2010Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6615-4438","authenticated-orcid":false,"given":"Jo B\u00f8nding","family":"Andreasen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2190-145X","authenticated-orcid":false,"given":"Bodil Steen","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg 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