{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:58:22Z","timestamp":1785376702494,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Burn injuries are associated with substantial morbidity and mortality worldwide, with infections representing a major complication. The desirable and undesirable effects of perioperative antibiotic prophylaxis in burn patients are unresolved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\/Design<\/jats:title>\n                    <jats:p>\n                      We will conduct a systematic review with meta\u2010analysis and trial sequential analysis of randomized clinical trials assessing the desirable and undesirable effects of systemic antibiotic prophylaxis in burn patients undergoing surgery, compared with placebo or no prophylaxis\/standard of care. The primary outcome will be the number of patients with one or more bloodstream infections. Secondary outcomes include 30\u2010day and 90\u2010day mortality, the number of patients with one or more skin and soft tissue infections, ventilator\u2010associated pneumonias,\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>clostridium difficile<\/jats:italic>\n                      <\/jats:styled-content>\n                      infections, antimicrobial\u2010resistant bacteria, serious adverse events, days alive without organ support (renal replacement therapy, mechanical ventilation, vasopressor), ICU\u2010 and hospital\u2010free days. We will search the following databases: CENTRAL, MEDLINE, EMBASE, BIOSIS, Web of Science, and CINAHL. The review will follow the recommendations provided by the Cochrane Handbook for Systematic Reviews of Interventions and the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses guidelines. The certainty of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation approach.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The outlined systematic review and meta\u2010analysis will evaluate the desirable and undesirable effects of perioperative antibiotic prophylaxis on patient\u2010important outcomes and may inform clinical practice and future research in this area.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov identifier: CRD420261378296\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.70273","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T23:17:01Z","timestamp":1781047021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Antibiotic Prophylaxis in Burn Patients: Protocol for a Systematic Review"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6018-4222","authenticated-orcid":false,"given":"Gustav Borghegn Blak","family":"Christensen","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Surgery and Trauma Centre Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6800-5858","authenticated-orcid":false,"given":"Hanna Kjems","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Surgery and Trauma Centre Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1612-0223","authenticated-orcid":false,"given":"Emma Atsuko","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Surgery and Trauma Centre Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2370-1657","authenticated-orcid":false,"given":"Marie","family":"Helleberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Infectious Diseases Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"},{"name":"Centre of Excellence for Health, Immunity and Infections Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5246-8727","authenticated-orcid":false,"given":"Mette","family":"Krag","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Surgery and Trauma Centre Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8176-404X","authenticated-orcid":false,"given":"Nicolai","family":"Haase","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Intensive Care Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6378-9673","authenticated-orcid":false,"given":"Morten Hylander","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Intensive Care Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7980-7979","authenticated-orcid":false,"given":"Martin Risom","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Surgery and Trauma Centre Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6579-461X","authenticated-orcid":false,"given":"Rikke","family":"Holmgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Plastic Surgery and Burn Treatment Copenhagen 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