{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:58:22Z","timestamp":1785376702535,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008218","name":"Gangstedfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008218","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Routine use of neuromuscular blocking agents (NMBAs) is widely recommended to facilitate tracheal intubation. However, NMBA use is associated with potential adverse effects, including postoperative respiratory complications, intraoperative awareness and anaphylaxis. Bolus remifentanil is an alternative, but evidence supporting its effectiveness on first\u2010pass success when using video laryngoscopy is sparse. We hypothesise that rocuronium reduces failed first\u2010pass and the risk of induction\u2010 or airway\u2010management\u2010related complications compared with bolus remifentanil when using a video laryngoscope.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      ROCVIDEO is a Danish\u2010Swedish, blinded, randomised, controlled trial comparing rocuronium (0.6\u2009mg\/kg) with remifentanil (4\u2009\u03bcg\/kg) at anaesthesia induction for facilitating orotracheal intubation using video laryngoscopy. Eligible adult participants (ASA\u2010class I\u2010III) undergoing general anaesthesia with video laryngoscopy\u2010assisted orotracheal intubation will be randomised to rocuronium or remifentanil in a ratio of 1:1. Anaesthesia will be induced with propofol and optional fentanyl or sufentanil. Intubation will be initiated 120\u2009s after administration of trial medicine. The two co\u2010primary outcomes are: (I) anaesthesia\u2010related adverse events and (II) failed first\u2010pass intubation. Secondary outcomes include patient satisfaction, length of stay in the post anaesthesia care unit and serious adverse events. The trial will randomise 2684 participants to be able to detect a 30% relative risk reduction in failed first pass intubation and anaesthesia\u2010related adverse events, with corresponding power of 80% and 99%, respectively, using a two\u2010sided\n                      <jats:italic>\u03b1<\/jats:italic>\n                      of 0.025.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Perspectives<\/jats:title>\n                    <jats:p>Given the global volume of tracheal intubation, even small differences may have substantial clinical implications. ROCVIDEO will generate high\u2010quality evidence to inform future guidelines aiming to improve global clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Status<\/jats:title>\n                    <jats:p>As of 15 June 2026, the trial has randomised 707 participants across 15 sites. Recruitment is expected to be completed in the third quarter of 2027.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      : NCT06564857; EUClinicalTrials.eu: 2025\u2010521405\u201040\u201001\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.70277","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:54:07Z","timestamp":1781672047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Remifentanil Versus Rocuronium for Optimising Video Laryngoscopy Assisted Tracheal Intubation\u2014The\n                    <scp>ROCVIDEO<\/scp>\n                    Trial Protocol"],"prefix":"10.1111","volume":"70","author":[{"given":"Emil \u00d8rskov","family":"Ipsen","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Copenhagen University Hospital\u2014North Zealand  Hilleroed Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2179-1433","authenticated-orcid":false,"given":"Lars Hyldborg","family":"Lundstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Copenhagen University Hospital\u2014North Zealand  Hilleroed Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Collaboration for Evidence\u2010Based Practice and Research in Anaesthesia (CEPRA)  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5se","family":"Lodenius","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Danderyd Hospital  Stockholm 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