{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:05:09Z","timestamp":1784693109171,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute kidney injury (AKI) is frequent and influences the prognosis of intensive care unit (ICU) patients. AKI may be categorised as contrast\u2010associated AKI (CA\u2010AKI). We investigated the development of CA\u2010AKI, including temporal and dose\u2013response relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients admitted between 2010 and 2015 with a minimum ICU stay of 54\u2009h were eligible for inclusion. AKI was scored on an hourly basis to enable temporal analyses. CA\u2010AKI was defined as an increase in Kidney Disease: Improving Global Outcomes (KDIGO) AKI stage occurring within 48\u2009h of contrast media administration. For the matched analysis, contrast\u2010exposed patients were matched to unexposed patients on duration of stay and renal function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1057 patients, 277 patients were exposed to contrast media. Sixteen percent (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200943) developed CA\u2010AKI (KDIGO AKI stage 1\/2\/3: 63%\/23%\/14%). AKI preceded contrast in 76.2% of cases (95% confidence interval [CI]: 66%\u201385%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). After contrast exposure, AKI reversal occurred in 65 cases. The proportion of CA\u2010AKI was similar between dose quartiles (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.746). The length of ICU stay (length of stay [LOS]) was longer in the exposed group (10.9 vs. 5.5\u2009days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) regardless of CA\u2010AKI status. In the matched analysis, exposed patients had longer remaining LOS (mean difference 1.47\u2009days, 95% CI: 1.35\u20131.60) and higher ICU mortality (OR: 1.67, 95% CI: 1.1\u20132.6), but use of renal replacement therapy (RRT) was similar.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CA\u2010AKI was observed in one of six ICU patients exposed to contrast media and associated with higher mortality and ICU LOS. However, AKI most often precedes contrast. AKI reversal was more common than AKI following exposure. No clear evidence of a dose\u2013response relationship was found. The findings question whether AKI in an ICU population is related to contrast media exposure, but the observational design precludes ruling out contrast media as a cause of AKI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Editorial Comment<\/jats:title>\n                    <jats:p>This ICU cohort analysis presents kidney injury findings where there is intravenous contrast exposure. Where some kidney injury was sometimes present before contrast exposure, this makes exploring the relation of contrast to injury and recovery more complex.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.70295","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:58:40Z","timestamp":1782881920000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Contrast Media and Acute Kidney Injury in the\n                    <scp>ICU<\/scp>"],"prefix":"10.1111","volume":"70","author":[{"given":"Skule","family":"Mo","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine St. Olavs Hospital, Trondheim University Hospital  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-8447","authenticated-orcid":false,"given":"P\u00e5l","family":"Klepstad","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine St. Olavs Hospital, Trondheim University Hospital  Trondheim Norway"},{"name":"Department of Circulation and Medical Imaging Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor W.","family":"Bjelland","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0052-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60126-X"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.02.385"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.7.813"},{"key":"e_1_2_10_6_1","volume-title":"ACR Manual on Contrast Media","author":"American College of Radiology","year":"2025"},{"key":"e_1_2_10_7_1","first-page":"1","article-title":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. 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