{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:05:44Z","timestamp":1789967144418,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prehospital administration of blood products is a growing practice. We aimed to describe clinical parameters and mortality following prehospital blood component therapy with red blood cells (RBC) and\/or plasma in patients with traumatic and non\u2010traumatic haemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An retrospective cohort study was performed on patients receiving prehospital transfusion products at the Danish national Helicopter Emergency Medical service between 2014 and 2020 with addition of a recent period 2023\u20132024. Data was collected from relevant data bases and electronic patient journals and analysed descriptively and statistically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 393 patients who received prehospital transfusion (280 trauma and 113 non\u2010trauma). Prehospital transfusion rate was low (0.9% of missions) with no change during the period studied. Mortality rates for the entire cohort were 13% at 24\u2009h and 26% at 30\u2009days. Trauma patients were significantly younger 49 (IQR; 28\u201368) vs. 71 (IQR; 60\u201377)), with lower Glasgow coma score scale; 3 (IQR; 3\u201314) vs. 15 (IQR; 3\u201315) and more days on ventilator; 3 (IQR; 1\u20138) days vs. 2 (IQR; 0\u20133) days), in intensive care; 5 (IQR; 2\u201312) days vs. 2 (IQR; 0\u20134) days) and longer hospital stay 16 (IQR; 6\u201338) days vs. 8 (IQR; 3\u201316) days). Lactate trauma\u2010group: 3.2 (IQR; 1.9\u20135.8), non\u2010trauma: 5.1 (IQR; 2.3\u20139.4) mmol\/L and base excess trauma\u2010group: \u22124.9 (IQR; \u22129 to \u22122.3), non\u2010trauma: \u22128 (IQR; \u221215.6 to \u22124) mmol\/L were outside reference range indicating circulatory shock at hospital arrival while standard coagulation parameters were normal or near\u2010normal. Mortality was significantly higher in non\u2010trauma patients as compared with trauma (11% vs. 22%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prehospital transfusion was uncommon, did not change over time and was associated with biochemical parameters near the normal reference range. Twenty\u2010four\u2010hour mortality was higher among non\u2010trauma patients compared with trauma patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Editorial Comment<\/jats:title>\n                    <jats:p>Some forms of advanced care can be delivered to critically ill or injured patients on their way emergently to hospital, for example in air ambulances. In this cohort of cases which included significant haemorrhage, administration of component blood products was analysed for associations with case conditions and health outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.70319","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T05:36:53Z","timestamp":1787549813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prehospital Transfusion With Red Blood Cells and Fresh Plasma in Helicopter Emergency Medical Services"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0189-6438","authenticated-orcid":false,"given":"Jesper Borg","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Amager and Hvidovre Hospital  Hvidovre Denmark"},{"name":"Search and Rescue The Danish Armed Forces  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarke","family":"Risgaard","sequence":"additional","affiliation":[{"name":"Department of Thoracic Anaesthesiology, the Heart Centre Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rico","family":"Schou","sequence":"additional","affiliation":[{"name":"The Danish Air Ambulance  Aarhus Denmark"},{"name":"Department of Anaesthesiology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dahl","sequence":"additional","affiliation":[{"name":"The Danish Air Ambulance  Aarhus Denmark"},{"name":"Department of Anaesthesiology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troels Martin","family":"Hansen","sequence":"additional","affiliation":[{"name":"The Danish Air Ambulance  Aarhus 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Air Ambulance  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Anesthesiology and Trauma Centre, Centre for Head and Orthopedics Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0536-560X","authenticated-orcid":false,"given":"Christian","family":"Fenger\u2010Eriksen","sequence":"additional","affiliation":[{"name":"The Danish Air Ambulance  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Anesthesiology Aarhus University Hospital  Aarhus 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