{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:40:34Z","timestamp":1792478434683,"version":"4.5.0"},"reference-count":64,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intrathecal morphine is widely used for postoperative analgesia following cesarean delivery. However, intrathecal morphine's potential association with hypothermia remains uncertain, although hypothermia may adversely affect maternal recovery and comfort. This scoping review aims to map the available evidence regarding temperature dysregulation associated with intrathecal morphine in patients undergoing cesarean delivery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a scoping review according to the PRISMA\u2010ScR guideline. A systematic literature search was performed in Medline, Embase, The Cochrane Library, and Cinahl. Studies reporting temperature outcomes in patients receiving intrathecal morphine during cesarean delivery were eligible. The primary outcome was the incidence of hypothermia or hyperthermia. Secondary outcomes included changes in core temperature, dose\u2013response relation, duration, severity of temperature dysregulation, and impact on recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 35 studies published between 1991 and 2025 were included. Four studies evaluated intrathecal morphine as intervention, whereas it was administered as standard care provided for all trial patients in the remaining studies. A total of 20 studies reported the incidence of hypothermia, corresponding to a pooled incidence of 21% among 773 patients. No studies reported an increase in temperature. A total of 12 case reports described severe hypothermia attributed to intrathecal morphine. However, our explorative analysis did not show an association between intrathecal morphine and hypothermia, and no dose response was identified. Clinical outcomes were infrequently reported, though several hypothermic patients were described as asymptomatic, suggesting that hypothermia may be clinically under\u2010recognized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Current evidence does not demonstrate a consistent association between intrathecal morphine and hypothermia following cesarean delivery. However, interpretation is limited by substantial heterogeneity across studies. This scoping review highlights an important evidence gap in the literature and supports the need for well\u2010designed studies to clarify whether intrathecal morphine contributes to clinically relevant hypothermia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Editorial Comment<\/jats:title>\n                    <jats:p>This review presents an overview of the evidence concerning intrathecal morphine treatment and post\u2010caesarean temperature dysregulation. The evidence is incomplete, and this scoping review highlights areas where higher quality evidence is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.70350","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:50:37Z","timestamp":1791157837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Temperature Dysregulation Following Intrathecal Morphine for Cesarean Delivery Patients\u2014A Scoping Review"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3074-927X","authenticated-orcid":false,"given":"Christina","family":"Draegert","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Zealand University Hospital  Roskilde Denmark"},{"name":"Department of Anesthesiology and Intensive Care Hvidovre University Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6289-6277","authenticated-orcid":false,"given":"Pernille","family":"Pape","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Hvidovre University Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Kruse","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5988-4563","authenticated-orcid":false,"given":"Helene K.","family":"Nedergaard","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care University Hospital of Southern Denmark  Kolding Denmark"},{"name":"Department of Regional Health Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6848-8143","authenticated-orcid":false,"given":"Anne J.","family":"Wikkels\u00f8","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Zealand University Hospital  Roskilde Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Caesarean birth NICE guideline [Internet]. 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