{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T12:18:38Z","timestamp":1777033118302,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T00:00:00Z","timestamp":1353888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>It has been known for more than four decades that during mammalian estrous cycles, luteinizing hormone stimulates a transitory rise in the ovaries of ornithine decarboxylase (<jats:styled-content style=\"fixed-case\">ODC<\/jats:styled-content>) activity and its enzymatic product putrescine, concurrent with oocyte maturation <jats:italic>in vivo<\/jats:italic>. Inhibition of this transitory <jats:styled-content style=\"fixed-case\">ODC<\/jats:styled-content>\/putrescine rise, however, does not appear to affect oocyte maturation or ovulation. Using several mouse models and combining <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> approaches, we demonstrated that deficiency of <jats:styled-content style=\"fixed-case\">ODC<\/jats:styled-content> during oocyte maturation is correlated with increased levels of egg aneuploidies. These results suggest that the transitory ovarian <jats:styled-content style=\"fixed-case\">ODC<\/jats:styled-content> rise in late proestrus is important for ensuring proper chromosome segregation during oocyte maturation. Older mice (8\u00a0months of age) exhibited about 1\/3 that of young mice in <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>\u2010stimulated ovarian <jats:styled-content style=\"fixed-case\">ODC<\/jats:styled-content> activity and a corresponding increase in egg aneuploidies. Moreover, a combination of putrescine supplementation in mouse drinking water leading up to oocyte retrieval and in oocyte maturation medium reduced egg aneuploidies of the older mice from 12.7% to 5.3%. Therefore, ovarian <jats:styled-content style=\"fixed-case\">ODC<\/jats:styled-content> deficiency might be an important etiology of maternal aging\u2010related aneuploidies, and peri\u2010ovulatory putrescine supplementation might reduce the risk of aneuploid conceptions in older women.<\/jats:p>","DOI":"10.1111\/acel.12016","type":"journal-article","created":{"date-parts":[[2012,10,13]],"date-time":"2012-10-13T13:41:33Z","timestamp":1350135693000},"page":"42-49","source":"Crossref","is-referenced-by-count":27,"title":["Deficiency of ovarian ornithine decarboxylase contributes to aging\u2010related egg aneuploidy in mice"],"prefix":"10.1111","volume":"12","author":[{"given":"Yong","family":"Tao","sequence":"first","affiliation":[{"name":"Ottawa Hospital Research Institute Ottawa Hospital\u2010General Campus Ottawa ON Canada"},{"name":"Faculty of Graduate and Postdoctoral Studies University of Ottawa Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. John\u00e9","family":"Liu","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute Ottawa Hospital\u2010General Campus Ottawa ON Canada"},{"name":"Faculty of Graduate and Postdoctoral Studies University of Ottawa Ottawa ON Canada"},{"name":"Department of Obstetrics and Gynaecology University of Ottawa Ottawa ON Canada"},{"name":"Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00201839"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/513890"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000133631"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi006"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2010.06.069"},{"key":"e_1_2_6_8_1","first-page":"176","article-title":"Association between nondisjunction and maternal age in meiosis\u2010II human oocytes","volume":"59","author":"Dailey T","year":"1996","journal-title":"Am. 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