{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:45:45Z","timestamp":1784036745273,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T00:00:00Z","timestamp":1367452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Science Foundation","award":["IOBO446240"],"award-info":[{"award-number":["IOBO446240"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["RO1AG02656101A1"],"award-info":[{"award-number":["RO1AG02656101A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The identification and characterization of age\u2010related degenerative changes is a critical goal because it can elucidate mechanisms of aging biology and contribute to understanding interventions that promote longevity. Here, we document a novel, age\u2010related degenerative change in <jats:italic>C.\u00a0elegans<\/jats:italic> hermaphrodites<jats:italic>,<\/jats:italic> an important model system for the genetic analysis of longevity. Matricidal hatching\u2014intra\u2010uterine hatching of progeny that causes maternal death\u2014displayed an age\u2010related increase in frequency and affected ~70% of mated, wild\u2010type hermaphrodites. The timing and incidence of matricidal hatching were largely independent of the levels of early and total progeny production and the duration of male exposure. Thus, matricidal hatching appears to reflect intrinsic age\u2010related degeneration of the egg\u2010laying system rather than use\u2010dependent damage accumulation. Consistent with this model, mutations that extend longevity by causing dietary restriction significantly delayed matricidal hatching, indicating age\u2010related degeneration of the egg\u2010laying system is controlled by nutrient availability. To identify the underlying tissue defect, we analyzed serotonin signaling that triggers vulval muscle contractions. Mated hermaphrodites displayed an age\u2010related decline in the ability to lay eggs in response to exogenous serotonin, indicating that vulval muscles and\/or a further downstream function that is necessary for egg laying degenerate in an age\u2010related manner. By characterizing a new, age\u2010related degenerative event displayed by <jats:italic>C.\u00a0elegans<\/jats:italic> hermaphrodites, these studies contribute to understanding a frequent cause of death in mated hermaphrodites and establish a model of age\u2010related reproductive complications that may be relevant to the birthing process in other animals such as humans.<\/jats:p>","DOI":"10.1111\/acel.12079","type":"journal-article","created":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T16:05:00Z","timestamp":1364832300000},"page":"544-553","source":"Crossref","is-referenced-by-count":49,"title":["Age\u2010related degeneration of the egg\u2010laying system promotes matricidal hatching in <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1111","volume":"12","author":[{"given":"Christopher L.","family":"Pickett","sequence":"first","affiliation":[{"name":"Department of Developmental Biology Washington University School of Medicine 660 South Euclid Ave. Campus Box 8103 St. Louis MO 63110 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Kornfeld","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology Washington University School of Medicine 660 South Euclid Ave. Campus Box 8103 St. Louis MO 63110 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000295"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/133.4.897"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1895\/wormbook.1.78.1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/77.1.71"},{"key":"e_1_2_7_6_1","first-page":"107","article-title":"Facultative vivipary is a life\u2010history trait in Caenorhabditis elegans","volume":"36","author":"Chen J","year":"2004","journal-title":"J 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