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Here, we show that <jats:styled-content style=\"fixed-case\">SRT<\/jats:styled-content>2104, a synthetic small molecule activator of <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>1, extends both mean and maximal lifespan of mice fed a standard diet. This is accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensitivity associated with higher mitochondrial content and decreased inflammation. Short\u2010term <jats:styled-content style=\"fixed-case\">SRT<\/jats:styled-content>2104 treatment preserves bone and muscle mass in an experimental model of atrophy. These results demonstrate it is possible to design a small molecule that can slow aging and delay multiple age\u2010related diseases in mammals, supporting the therapeutic potential of <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>1 activators in humans.<\/jats:p>","DOI":"10.1111\/acel.12220","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T22:53:15Z","timestamp":1402959195000},"page":"787-796","source":"Crossref","is-referenced-by-count":228,"title":["<scp>SRT<\/scp>2104 extends survival of male mice on a standard diet and preserves bone and muscle mass"],"prefix":"10.1111","volume":"13","author":[{"given":"Evi M.","family":"Mercken","sequence":"first","affiliation":[{"name":"Translational Gerontology Branch National Institute on Aging National Institutes of Health Baltimore MD 21224 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah 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