{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:41:20Z","timestamp":1791304880537,"version":"4.3.1"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T00:00:00Z","timestamp":1399852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001590","name":"Health Research Board (HRB)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001590","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Department of Employment and Learning (DEL)"},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Aging results in deterioration of the immune system, which is associated with increased susceptibility to infection and impaired wound healing in the elderly. Phagocytosis is an essential process in both wound healing and immune defence. As such, age\u2010related impairments in phagocytosis impact on the health of the elderly population. Phagocytic efficiency in peritoneal macrophages, bone marrow\u2010derived macrophages and bone marrow monocytes from young and old mice was investigated. Aging significantly impaired phagocytosis by peritoneal macrophages, both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. However, bone marrow\u2010derived macrophages and bone marrow monocytes did not exhibit age\u2010related impairments in phagocytosis, suggesting no intrinsic defect in these cells. We sought to investigate underlying mechanisms in age\u2010related impairments in phagocytosis by peritoneal macrophages. We hypothesized that microenvironmental factors in the peritoneum of old mice impaired macrophage phagocytosis. Indeed, macrophages from young mice injected into the peritoneum of old mice exhibited impaired phagocytosis. Proportions of peritoneal immune cells were characterized, and striking increases in numbers of T cells, B1 and B2 cells were observed in the peritoneum of old mice compared with young mice. In addition, B cell\u2010derived <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 was increased in resting and <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010activated peritoneal cell cultures from old mice. These data demonstrate that aging impairs phagocytosis by tissue\u2010resident peritoneal macrophages, but not by bone marrow\u2010derived macrophages\/monocytes, and suggest that age\u2010related defects in macrophage phagocytosis may be due to extrinsic factors in the tissue microenvironment. As such, defects may be reversible and macrophages could be targeted therapeutically in order to boost immune function in the elderly.<\/jats:p>","DOI":"10.1111\/acel.12223","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T06:24:50Z","timestamp":1399875890000},"page":"699-708","source":"Crossref","is-referenced-by-count":156,"title":["Aging impairs peritoneal but not bone marrow\u2010derived macrophage phagocytosis"],"prefix":"10.1111","volume":"13","author":[{"given":"Eimear","family":"Linehan","sequence":"first","affiliation":[{"name":"Centre for Infection and Immunity Queen's University Belfast 97 Lisburn Road Belfast BT9 7AE Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Dombrowski","sequence":"additional","affiliation":[{"name":"Centre for Infection and Immunity Queen's University Belfast 97 Lisburn Road Belfast BT9 7AE Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Snoddy","sequence":"additional","affiliation":[{"name":"Centre for Infection and Immunity Queen's University Belfast 97 Lisburn Road Belfast BT9 7AE Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padraic G.","family":"Fallon","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine St. James's Hospital Trinity College Dublin Dublin 2 Ireland"},{"name":"National Children's Research Centre Our Lady's Children's Hospital Crumlin Dublin 8 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Kissenpfennig","sequence":"additional","affiliation":[{"name":"Centre for Infection and Immunity Queen's University Belfast 97 Lisburn Road Belfast BT9 7AE Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise C.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Centre for Infection and Immunity Queen's University Belfast 97 Lisburn Road Belfast BT9 7AE Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03658.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1127"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0803389"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0804449"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.10.4288-4298.1996"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(85)90933-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.4049\/jimmunol.153.5.2146","article-title":"Effect of aging on murine macrophages. 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