{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:13:06Z","timestamp":1761595986758,"version":"3.41.2"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T00:00:00Z","timestamp":1399334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Korean Government (MEST)","award":["NRF-2012R1A2A1A03006092"],"award-info":[{"award-number":["NRF-2012R1A2A1A03006092"]}]},{"name":"Korean Health Technology R&D Project"},{"name":"Ministry of Health and Welfare, the Republic of Korea","award":["A121443"],"award-info":[{"award-number":["A121443"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The liver is one of the most susceptible organs to aging, and hepatic inflammation and fibrosis increase with age. Chronic inflammation has been proposed as the major molecular mechanism underlying aging and age\u2010related diseases, whereas calorie restriction has been shown to be the most effective in extending mammalian lifespan and to have anti\u2010aging effects through its anti\u2010inflammatory action. Thus, it is necessary to develop effective calorie restriction mimetics. Daumone [(2)\u2010(6R)\u2010(3,5\u2010dihydroxy\u20106\u2010methyltetrahydropyran\u20102\u2010yloxy)heptanoic acid], a pheromone secreted by <jats:italic>Caenorhabditis elegans<\/jats:italic>, forces them to enter the dauer stage when facing inadequate conditions. Because <jats:italic>Caenorhabditis elegans<\/jats:italic> live longer during the dauer stage under energy deprivation, it was hypothesized that daumone may improve survival in mammals by mimicking calorie restriction. Daumone (2\u00a0mg kg<jats:sup>\u22121<\/jats:sup> day<jats:sup>\u22121<\/jats:sup>) was administered orally for 5\u00a0months to 24\u2010month\u2010old male C57BL\/6J mice. Daumone was found to reduce the risk of death by 48% compared with age\u2010matched control mice, and the increased plasma insulin normally presented in old mice was significantly reduced by daumone. The increased hepatic hypertrophy, senescence\u2010associated \u03b2\u2010galactosidase activity, insulin resistance, lipid accumulation, inflammation, oxidative stress, and fibrosis in old mice were significantly attenuated by daumone. From a mechanistic view, daumone reduced the phosphorylation of the I\u03baB\u03b1 and upregulation of <jats:italic>Rela<\/jats:italic> and <jats:italic>Nfkbia <\/jats:italic><jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> in the livers of old mice. The anti\u2010inflammatory effect of daumone was confirmed in lipopolysaccharide\u2010induced liver injury model. Oral administration of daumone improves survival in mice and delivers anti\u2010aging effects to the aged liver by modulating chronic inflammation, indicating that daumone could be developed as an anti\u2010aging compound.<\/jats:p>","DOI":"10.1111\/acel.12224","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T03:23:59Z","timestamp":1399346639000},"page":"709-718","source":"Crossref","is-referenced-by-count":15,"title":["Daumone fed late in life improves survival and reduces hepatic inflammation and fibrosis in mice"],"prefix":"10.1111","volume":"13","author":[{"given":"Jong Hee","family":"Park","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences College of Pharmacy Ewha Womans University Global Top 5 Research Program 52 Ewhayoedae\u2010gil, Seodaemun\u2010gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae Young","family":"Chung","sequence":"additional","affiliation":[{"name":"Aging Tissue Bank Department of Pharmacy College of Pharmacy Pusan National University 2 Busandaehak\u2010ro 63beon\u2010gil, Geumjeong\u2010gu Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minkyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry Yonsei University 50 Yonsei\u2010ro, Seodaemun\u2010gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hwa","family":"Lee","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences College of Pharmacy Ewha Womans University Global Top 5 Research Program 52 Ewhayoedae\u2010gil, Seodaemun\u2010gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mankil","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Chemistry Yonsei University 50 Yonsei\u2010ro, Seodaemun\u2010gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hunjoo","family":"Ha","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences College of Pharmacy Ewha Womans University Global Top 5 Research Program 52 Ewhayoedae\u2010gil, Seodaemun\u2010gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9728.2004.00097.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1166"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10203"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510387794"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.20.9363"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020443"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-012-9409-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.08.017"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1999.tb01583.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172539"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.03.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6896933"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24713"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.119"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08221"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1990.9.777"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/152308601750100669"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1324"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1895\/wormbook.1.144.1"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2010.00724.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1498"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03201"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004162"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-8556-6_11"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3192"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glq178"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep00070"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.01.031"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.178"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(96)01780-0"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2011.04.008"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.1649"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203239"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.06.011"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)00097-0"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.2.5.9579"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00521.2005"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(99)00012-3"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-008-9187-x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-2907-z"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25711"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061620"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/145.3.715"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facel.12224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facel.12224","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.12224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.12224","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.12224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T13:14:10Z","timestamp":1752844450000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.12224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,6]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/acel.12224"],"URL":"https:\/\/doi.org\/10.1111\/acel.12224","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"type":"print","value":"1474-9718"},{"type":"electronic","value":"1474-9726"}],"subject":[],"published":{"date-parts":[[2014,5,6]]}}}