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Five\u2010week\u2010old vehicle\u2010treated <jats:italic>Bmi\u20101<\/jats:italic><jats:sup><jats:italic>\u2010\/\u2010<\/jats:italic><\/jats:sup> mice displayed renal interstitial fibrosis, tubular atrophy, and severe renal function impairment with decreased renal cell proliferation, increased renal cell apoptosis and senescence, and inflammatory cell infiltration. Impaired mitochondrial structure, decreased mitochondrial numbers, and increased oxidative stress occurred in <jats:italic>Bmi\u20101<\/jats:italic><jats:sup><jats:italic>\u2010\/\u2010<\/jats:italic><\/jats:sup> mice; subsequently, this caused <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage, the activation of <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21\/Smad signaling, and the imbalance between extracellular matrix synthesis and degradation. Oxidative stress\u2010induced epithelial\u2010to\u2010mesenchymal transition of renal tubular epithelial cells was enhanced in <jats:italic>Bmi\u20101<\/jats:italic> knocked down <jats:styled-content style=\"fixed-case\">HK<\/jats:styled-content>2 cells. All phenotypic alterations caused by <jats:italic>Bmi\u20101<\/jats:italic> deficiency were ameliorated by antioxidant treatment. These findings indicate that <jats:italic>Bmi\u20101<\/jats:italic> plays a critical role in protection from renal tubulointerstitial injury by maintaining redox balance and will be a novel therapeutic target for preventing renal tubulointerstitial injury.<\/jats:p>","DOI":"10.1111\/acel.12236","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T07:39:32Z","timestamp":1402472372000},"page":"797-809","source":"Crossref","is-referenced-by-count":38,"title":["RETRACTED: Bmi\u20101 plays a critical role in protection from renal tubulointerstitial injury by maintaining redox balance"],"prefix":"10.1111","volume":"13","author":[{"given":"Jianliang","family":"Jin","sequence":"first","affiliation":[{"name":"The State Key Laboratory of Reproductive Medicine Department of Anatomy Histology and Embryology Nanjing Medical University Nanjing 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