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Using human diploid fibroblasts (\n                    <jats:styled-content style=\"fixed-case\">HDF<\/jats:styled-content>\n                    ), we report here that MetR significantly extends their replicative lifespan, thereby postponing cellular senescence. MetR significantly decreased activity of mitochondrial complex\n                    <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                    and diminished the accumulation of reactive oxygen species. Lifespan extension was accompanied by a significant decrease in the levels of subunits of mitochondrial complex\n                    <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                    , but also complex I, which was due to a decreased translation rate of several mt\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    \u2010encoded subunits. Together, these findings indicate that MetR slows down aging in human cells by modulating mitochondrial protein synthesis and respiratory chain assembly.\n                  <\/jats:p>","DOI":"10.1111\/acel.12266","type":"journal-article","created":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T00:05:16Z","timestamp":1412208316000},"page":"1038-1048","source":"Crossref","is-referenced-by-count":64,"title":["Methionine restriction slows down senescence in human diploid fibroblasts"],"prefix":"10.1111","volume":"13","author":[{"given":"Rafa\u0142","family":"Kozie\u0142","sequence":"first","affiliation":[{"name":"Institute for Biomedical Aging Research (IBA) Universit\u00e4t Innsbruck Rennweg 10 6020 Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Ruckenstuhl","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biosciences Karl\u2010Franzens University Humboldtstrasse 50 8010 Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Albertini","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Aging Research (IBA) Universit\u00e4t Innsbruck Rennweg 10 6020 Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Neuhaus","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Aging Research (IBA) Universit\u00e4t Innsbruck Rennweg 10 6020 Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Netzberger","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biosciences Karl\u2010Franzens University Humboldtstrasse 50 8010 Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bust","sequence":"additional","affiliation":[{"name":"Institute for Vegetative Physiology University of K\u00f6ln Robert\u2010Kochstr. 39 50931 K\u00f6ln Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Madeo","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biosciences Karl\u2010Franzens University Humboldtstrasse 50 8010 Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf J.","family":"Wiesner","sequence":"additional","affiliation":[{"name":"Institute for Vegetative Physiology University of K\u00f6ln Robert\u2010Kochstr. 39 50931 K\u00f6ln Germany"},{"name":"Center for Molecular Medicine Cologne University of K\u00f6ln Robert\u2010Kochstr. 21 50931 K\u00f6ln Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010associated Diseases (CECAD) Joseph\u2010Stelzmannstr. 26 50931 K\u00f6ln Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pidder","family":"Jansen\u2010D\u00fcrr","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Aging Research (IBA) Universit\u00e4t Innsbruck Rennweg 10 6020 Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10600"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth866"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5349.349"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20110162"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2010.10.005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-008-9130-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2009.0902"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(76)90038-1"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(96)64020-8"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.2438"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn030"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.01.022"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20091714"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20090214"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08619"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2006.00267.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00837.2009"},{"key":"e_1_2_10_20_1","first-page":"1180","article-title":"Mortality and immortality at the cellular level. 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