{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:29:48Z","timestamp":1792567788102,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T00:00:00Z","timestamp":1418256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["RN231004"],"award-info":[{"award-number":["RN231004"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000233","name":"Genome British Columbia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000233","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Extracellular matrix (\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    ) degradation is a hallmark of many chronic inflammatory diseases that can lead to a loss of function, aging, and disease progression. Ultraviolet light (\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    ) irradiation from the sun is widely considered as the major cause of visible human skin aging, causing increased inflammation and enhanced\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    degradation. Granzyme B (GzmB), a serine protease that is expressed by a variety of cells, accumulates in the extracellular milieu during chronic inflammation and cleaves a number of\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    proteins. We hypothesized that GzmB contributes to\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    degradation in the skin after\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    irradiation through both direct cleavage of\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    proteins and indirectly through the induction of other proteinases. Wild\u2010type and GzmB\u2010knockout mice were repeatedly exposed to minimal erythemal doses of solar\u2010simulated\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    irradiation for 20\u00a0weeks. GzmB expression was significantly increased in wild\u2010type treated skin compared to nonirradiated controls, colocalizing to keratinocytes and to an increased mast cell population. GzmB deficiency significantly protected against the formation of wrinkles and the loss of dermal collagen density, which was related to the cleavage of decorin, an abundant proteoglycan involved in collagen fibrillogenesis and integrity. GzmB also cleaved fibronectin, and GzmB\u2010mediated fibronectin fragments increased the expression of collagen\u2010degrading matrix metalloproteinase\u20101 (\n                    <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                    \u20101) in fibroblasts. Collectively, these findings indicate a significant role for GzmB in\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    degradation that may have implications in many age\u2010related chronic inflammatory diseases.\n                  <\/jats:p>","DOI":"10.1111\/acel.12298","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T06:23:38Z","timestamp":1418279018000},"page":"67-77","source":"Crossref","is-referenced-by-count":98,"title":["Granzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low\u2010dose ultraviolet light irradiation"],"prefix":"10.1111","volume":"14","author":[{"given":"Leigh G.","family":"Parkinson","sequence":"first","affiliation":[{"name":"Centre for Heart Lung Innovation St. Paul's Hospital Vancouver British Columbia Canada"},{"name":"Department of Pathology and Laboratory Medicine University of British Columbia Vancouver British 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