{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:28:46Z","timestamp":1792798126240,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T00:00:00Z","timestamp":1425600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Major Program of National Natural Science Fundation of China","award":["81490742"],"award-info":[{"award-number":["81490742"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Increased fat mass and fat redistribution are commonly observed in aging populations worldwide. Although decreased circulating levels of sex hormones, androgens and oestrogens have been observed, the exact mechanism of fat accumulation and redistribution during aging remains obscure. In this study, the receptor of follicle\u2010stimulating hormone (\n                    <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>\n                    ), a gonadotropin that increases sharply and persistently with aging in both males and females, is functionally expressed in human and mouse fat tissues and adipocytes. Follicle\u2010stimulating hormone was found to promote lipid biosynthesis and lipid droplet formation;\n                    <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>\n                    could also alter the secretion of leptin and adiponectin, but not hyperplasia,\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . The effects of\n                    <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>\n                    are mediated by\n                    <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>\n                    receptors coupled to the G\u03b1i protein; as a result, Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx is stimulated, c\n                    <jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content>\n                    \u2010response\u2010element\u2010binding protein is phosphorylated, and an array of genes involved in lipid biosynthesis is activated. The present findings depict the potential of\n                    <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>\n                    receptor\u2010mediated lipodystrophy of adipose tissues in aging. Our results also reveal the mechanism of fat accumulation and redistribution during aging of males and females.\n                  <\/jats:p>","DOI":"10.1111\/acel.12331","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T11:04:54Z","timestamp":1425639894000},"page":"409-420","source":"Crossref","is-referenced-by-count":161,"title":["FSH regulates fat accumulation and redistribution in aging through the G\u03b1i\/Ca\n                    <sup>2+<\/sup>\n                    \/CREB pathway"],"prefix":"10.1111","volume":"14","author":[{"given":"Xin\u2010Mei","family":"Liu","sequence":"first","affiliation":[{"name":"International Peace Maternity and Child Health Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"},{"name":"Department of Pathology &amp; Pathophysiology School of Medicine Zhejiang University Zhejiang China"},{"name":"Shanghai Jiao Tong University \u2013 The Chinese University of Hong Kong Joint Research Center for Human Reproduction and Related Diseases Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao Chang","family":"Chan","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University \u2013 The Chinese University of Hong Kong Joint Research Center for Human Reproduction and Related Diseases Shanghai China"},{"name":"Epithelial Cell Biology Research Center School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Hong Kong Hong Kong"},{"name":"Key Laboratory for Regenerative Medicine (Jinan University \u2013 The Chinese University of Hong Kong) Ministry of Education Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Lian","family":"Ding","sequence":"additional","affiliation":[{"name":"International Peace Maternity and Child Health Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"},{"name":"Shanghai Jiao Tong University \u2013 The Chinese University of Hong Kong Joint Research Center for Human Reproduction and Related Diseases Shanghai China"},{"name":"The Key Laboratory of Reproductive Genetics Ministry of Education Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Cai","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Reproductive Genetics Ministry of Education Hangzhou China"},{"name":"Ningbo Maternal and Child Health Hospital Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Song","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Reproductive Genetics Ministry of Education Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Reproductive Genetics Ministry of Education Hangzhou 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Chinese University of Hong Kong Joint Research Center for Human Reproduction and Related Diseases Shanghai China"},{"name":"Epithelial Cell Biology Research Center School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Hong Kong Hong Kong"},{"name":"Key Laboratory for Regenerative Medicine (Jinan University \u2013 The Chinese University of Hong Kong) Ministry of Education Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Ting","family":"Wu","sequence":"additional","affiliation":[{"name":"International Peace Maternity and Child Health Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"},{"name":"Shanghai Jiao Tong University \u2013 The Chinese University of Hong Kong Joint Research Center for Human Reproduction and Related Diseases Shanghai China"},{"name":"The Key Laboratory of Reproductive Genetics Ministry of Education Hangzhou 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