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Microtubule\u2010associated protein <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>1S interacts with autophagy marker <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>3 and positively regulates autophagy flux. <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>3 binds with <jats:italic>fibronectin<\/jats:italic><jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and facilitates its translation. The synthesized fibronectin protein is exported to cell surface to initiate the assembly of fibronectin extracellular matrix. Fibronectin is degraded in lysosomes after it is engulfed into cytosol via endocytosis. Here, we show that defects in <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>1S\u2010mediated autophagy trigger oxidative stress, sinusoidal dilation, and lifespan reduction. Overexpression of <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>3 in wild\u2010type mice increases the levels of fibronectin and \u03b3\u2010H<jats:sub>2<\/jats:sub><jats:styled-content style=\"fixed-case\">AX<\/jats:styled-content>, a marker of <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> double\u2010strand breakage. <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>3\u2010induced fibronectin is efficiently degraded in lysosomes to maintain a balance of fibronectin levels in wild\u2010type mice so that the mice live a normal term of lifespan. In the <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>3 transgenic mice with <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>1S deleted, <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>3 enhances the synthesis of fibronectin but the <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>1S depletion causes an impairment of the lysosomal degradation of fibronectin. The accumulation of fibronectin protein promotes liver fibrosis, induces an accumulation of cell population at the G0\/G1 stage, and further intensifies oxidative stress and sinusoidal dilatation. The <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>3\u2010induced overexpression of fibronectin imposes stresses on <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>1S\u2010deficient mice and dramatically reduces their lifespans. Therefore, <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>1S\u2010mediated autophagy plays an important role in maintaining mouse lifespan especially in the presence of extra amount of fibronectin.<\/jats:p>","DOI":"10.1111\/acel.12441","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T04:38:28Z","timestamp":1452487108000},"page":"370-379","source":"Crossref","is-referenced-by-count":23,"title":["Defects in <scp>MAP<\/scp>1S\u2010mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed"],"prefix":"10.1111","volume":"15","author":[{"given":"Wenjiao","family":"Li","sequence":"first","affiliation":[{"name":"Center for Translational Cancer Research Institute of Biosciences and Technology Texas A&amp;M Health Science Center 2121\u00a0W. Holcombe Blvd. Houston TX 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zou","sequence":"additional","affiliation":[{"name":"Center for Translational Cancer Research Institute of Biosciences and Technology Texas A&amp;M Health Science Center 2121\u00a0W. Holcombe Blvd. Houston TX 77030 USA"},{"name":"Department of ophthalmology Xiangya Hospital Central South University Changsha Hunan 410008 China"},{"name":"Jiangxi Research Institute of Ophthalmology and Visual Sciences The Affiliated Eye Hospital of Nanchang University Nanchang 330006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yue","sequence":"additional","affiliation":[{"name":"Center for Translational Cancer Research Institute of Biosciences and Technology Texas A&amp;M Health Science Center 2121\u00a0W. Holcombe Blvd. Houston TX 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Song","sequence":"additional","affiliation":[{"name":"Center for Translational Cancer Research Institute of Biosciences and Technology Texas A&amp;M Health Science Center 2121\u00a0W. Holcombe Blvd. Houston TX 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Translational Cancer Research Institute of Biosciences and Technology Texas A&amp;M Health Science Center 2121\u00a0W. Holcombe Blvd. Houston TX 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wallace L.","family":"McKeehan","sequence":"additional","affiliation":[{"name":"Center for Translational Cancer Research Institute of Biosciences and Technology Texas A&amp;M Health Science Center 2121\u00a0W. Holcombe Blvd. Houston TX 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Translational Cancer Research Institute of Biosciences and Technology Texas A&amp;M Health Science Center 2121\u00a0W. Holcombe Blvd. Houston TX 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guibin","family":"Xu","sequence":"additional","affiliation":[{"name":"Center for Translational Cancer Research Institute of Biosciences and Technology Texas A&amp;M Health Science Center 2121\u00a0W. Holcombe Blvd. Houston TX 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Huang","sequence":"additional","affiliation":[{"name":"Center for Translational Cancer Research Institute of Biosciences and Technology Texas A&amp;M Health Science Center 2121\u00a0W. Holcombe Blvd. Houston TX 77030 USA"},{"name":"Department of Urology The Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou 510120 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglin","family":"Yi","sequence":"additional","affiliation":[{"name":"Jiangxi Research Institute of Ophthalmology and Visual Sciences The Affiliated Eye Hospital of Nanchang University Nanchang 330006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Translational Cancer Research Institute of Biosciences and Technology Texas A&amp;M Health Science Center 2121\u00a0W. Holcombe Blvd. Houston TX 77030 USA"},{"name":"Jiangxi Research Institute of Ophthalmology and Visual Sciences The Affiliated Eye Hospital of Nanchang University Nanchang 330006 China"},{"name":"Department of Molecular and Cellular Medicine College of Medicine Texas A&amp;M Health Science Center College Station TX 77843 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i20.2482"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v3.i2.45"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21392"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-112904"},{"key":"e_1_2_9_6_1","first-page":"393","article-title":"Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor\u2010derived myofibroblasts","volume":"39","author":"Wever O","year":"2011","journal-title":"Int. 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