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These distinguished characteristics include the tissues where they are distributed or located, enzymatic activities, molecular functions, and involvement in diseases. Among the sirtuin members,<jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>3 has received much attention for its role in cancer genetics, aging, neurodegenerative disease, and stress resistance.<jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>3 controls energy demand during stress conditions such as fasting and exercise as well as metabolism through the deacetylation and acetylation of mitochondrial enzymes.<jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>3 is well known for its ability to eliminate reactive oxygen species and to prevent the development of cancerous cells or apoptosis. This review article provides a comprehensive review on numerous (noteworthy) molecular functions of<jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>3 and its effect on cancer cells and various diseases including Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease.<\/jats:p>","DOI":"10.1111\/acel.12538","type":"journal-article","created":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T04:13:04Z","timestamp":1475208784000},"page":"4-16","source":"Crossref","is-referenced-by-count":301,"title":["Function of the<scp>SIRT<\/scp>3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease"],"prefix":"10.1111","volume":"16","author":[{"given":"Aneesa","family":"Ansari","sequence":"first","affiliation":[{"name":"Department of Genetic Engineering and Biotechnology Jessore University of Science and Technology Jessore 7408 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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