{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T05:18:23Z","timestamp":1791695903169,"version":"4.3.4"},"reference-count":108,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T00:00:00Z","timestamp":1485388800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T00:00:00Z","timestamp":1485388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1111\/acel.12562","type":"journal-article","created":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T03:22:44Z","timestamp":1485400964000},"page":"210-218","source":"Crossref","is-referenced-by-count":329,"title":["Cellular senescence in osteoarthritis pathology"],"prefix":"10.1111","volume":"16","author":[{"given":"Kendal","family":"McCulloch","sequence":"first","affiliation":[{"name":"Institute of Biomedical and Environmental Health Research; University of the West of Scotland; Paisley PA1 2BE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary J.","family":"Litherland","sequence":"additional","affiliation":[{"name":"Institute of Biomedical and Environmental Health Research; University of the West of Scotland; Paisley PA1 2BE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7276-7492","authenticated-orcid":false,"given":"Taranjit Singh","family":"Rai","sequence":"additional","affiliation":[{"name":"Institute of Biomedical and Environmental Health Research; University of the West of Scotland; Paisley PA1 2BE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,26]]},"reference":[{"key":"10.1111\/acel.12562-BIB0001|acel12562-cit-0001","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.cell.2008.03.038","article-title":"Chemokine signaling via the CXCR2 receptor reinforces senescence","volume":"133","author":"Acosta","year":"2008","journal-title":"Cell"},{"key":"10.1111\/acel.12562-BIB0002|acel12562-cit-0002","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ncb2784","article-title":"A complex secretory program orchestrated by the inflammasome controls paracrine senescence","volume":"15","author":"Acosta","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1111\/acel.12562-BIB0003|acel12562-cit-0003","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nrc2440","article-title":"Living on a break: cellular senescence as a DNA-damage response","volume":"8","author":"d'Adda di Fagagna","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1111\/acel.12562-BIB0004|acel12562-cit-0004","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature02118","article-title":"A DNA damage checkpoint response in telomere-initiated senescence","volume":"426","author":"d'Adda di Fagagna","year":"2003","journal-title":"Nature"},{"key":"10.1111\/acel.12562-BIB0005|acel12562-cit-0005","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1002\/1529-0131(200106)44:6<1304::AID-ART222>3.0.CO;2-T","article-title":"Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee cartilage","volume":"44","author":"Aigner","year":"2001","journal-title":"Arthritis Rheum."},{"key":"10.1111\/acel.12562-BIB0006|acel12562-cit-0006","doi-asserted-by":"publisher","DOI":"10.1002\/term.2148","article-title":"RHEB: a potential regulator of chondrocyte phenotype for cartilage tissue regeneration","author":"Ashraf","year":"2016","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1111\/acel.12562-BIB0007|acel12562-cit-0007","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/ncb1744","article-title":"Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency","volume":"10","author":"Baker","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1111\/acel.12562-BIB0008|acel12562-cit-0008","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature10600","article-title":"Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders","volume":"479","author":"Baker","year":"2011","journal-title":"Nature"},{"key":"10.1111\/acel.12562-BIB0009|acel12562-cit-0009","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.celrep.2013.03.028","article-title":"p21 both attenuates and drives senescence and aging in BubR1 progeroid mice","volume":"3","author":"Baker","year":"2013","journal-title":"Cell Rep."},{"key":"10.1111\/acel.12562-BIB0010|acel12562-cit-0010","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature16932","article-title":"Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan","volume":"530","author":"Baker","year":"2016","journal-title":"Nature"},{"key":"10.1111\/acel.12562-BIB0011|acel12562-cit-0011","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1136\/ard.2004.025270","article-title":"Synovial tissue inflammation in early and late osteoarthritis","volume":"64","author":"Benito","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1111\/acel.12562-BIB0012|acel12562-cit-0012","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1172\/JCI119316","article-title":"Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage","volume":"99","author":"Billinghurst","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1111\/acel.12562-BIB0013|acel12562-cit-0013","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1136\/annrheumdis-2015-207742","article-title":"Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis","volume":"75","author":"Bouderlique","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1111\/acel.12562-BIB0014|acel12562-cit-0014","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1084\/jem.173.3.569","article-title":"Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts","volume":"173","author":"Bucala","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1111\/acel.12562-BIB0015|acel12562-cit-0015","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1096\/fj.12-206367","article-title":"cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis","volume":"26","author":"Bui","year":"2012","journal-title":"FASEB J."},{"key":"10.1111\/acel.12562-BIB0016|acel12562-cit-0016","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.cell.2012.12.010","article-title":"Monitoring tumorigenesis and senescence in\u00a0vivo with a p16(INK4a)-luciferase model","volume":"152","author":"Burd","year":"2013","journal-title":"Cell"},{"key":"10.1111\/acel.12562-BIB0017|acel12562-cit-0017","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1196\/annals.1404.026","article-title":"Cyclin D1 overexpression permits the reproducible detection of senescent human vascular smooth muscle cells","volume":"1119","author":"Burton","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1111\/acel.12562-BIB0018|acel12562-cit-0018","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cell.2005.02.003","article-title":"Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors","volume":"120","author":"Campisi","year":"2005","journal-title":"Cell"},{"key":"10.1111\/acel.12562-BIB0019|acel12562-cit-0019","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/art.27305","article-title":"Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis","volume":"62","author":"Carames","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1111\/acel.12562-BIB0020|acel12562-cit-0020","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1002\/art.39073","article-title":"The relationship of autophagy defects to cartilage damage during joint aging in a mouse model","volume":"67","author":"Carames","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1111\/acel.12562-BIB0021|acel12562-cit-0021","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nm.4010","article-title":"Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice","volume":"22","author":"Chang","year":"2016","journal-title":"Nat. Med."},{"key":"10.1111\/acel.12562-BIB0022|acel12562-cit-0022","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1359\/jbmr.2001.16.2.309","article-title":"A novel cell culture model of chondrocyte differentiation during mammalian endochondral ossification","volume":"16","author":"Cheung","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1111\/acel.12562-BIB0023|acel12562-cit-0023","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/path.1462","article-title":"Apoptosis of terminal hypertrophic chondrocytes in an in\u00a0vitro model of endochondral ossification","volume":"201","author":"Cheung","year":"2003","journal-title":"J. Pathol."},{"key":"10.1111\/acel.12562-BIB0024|acel12562-cit-0024","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.aaf6659","article-title":"Senescent intimal foam cells are deleterious at all stages of atherosclerosis","volume":"354","author":"Childs","year":"2016","journal-title":"Science"},{"key":"10.1111\/acel.12562-BIB0025|acel12562-cit-0025","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1136\/annrheumdis-2013-204763","article-title":"The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study","volume":"73","author":"Cross","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1111\/acel.12562-BIB0026|acel12562-cit-0026","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1038\/ncb2879","article-title":"Senescent cells harbour features of the cancer epigenome","volume":"15","author":"Cruickshanks","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1111\/acel.12562-BIB0027|acel12562-cit-0027","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/art.37965","article-title":"Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation","volume":"65","author":"Culley","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1111\/acel.12562-BIB0028|acel12562-cit-0028","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/(SICI)1097-4644(20000615)77:4<678::AID-JCB15>3.0.CO;2-P","article-title":"MMP-13 is induced during chondrocyte hypertrophy","volume":"77","author":"D'Angelo","year":"2000","journal-title":"J. Cell. Biochem."},{"key":"10.1111\/acel.12562-BIB0029|acel12562-cit-0029","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.cell.2011.08.017","article-title":"BET bromodomain inhibition as a therapeutic strategy to target c-Myc","volume":"146","author":"Delmore Jake","year":"2011","journal-title":"Cell"},{"key":"10.1111\/acel.12562-BIB0030|acel12562-cit-0030","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.4161\/cc.7.21.6919","article-title":"Growth stimulation leads to cellular senescence when the cell cycle is blocked","volume":"7","author":"Demidenko","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1111\/acel.12562-BIB0031|acel12562-cit-0031","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ccr.2009.02.022","article-title":"Oncogenic Braf induces melanocyte senescence and melanoma in mice","volume":"15","author":"Dhomen","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1111\/acel.12562-BIB0032|acel12562-cit-0032","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1101\/gad.8.21.2540","article-title":"DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts","volume":"8","author":"Leonardo","year":"1994","journal-title":"Genes Dev."},{"key":"10.1111\/acel.12562-BIB0033|acel12562-cit-0033","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nature05327","article-title":"Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication","volume":"444","author":"Di Micco","year":"2006","journal-title":"Nature"},{"key":"10.1111\/acel.12562-BIB0034|acel12562-cit-0034","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/ncb2170","article-title":"Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer","volume":"13","author":"Di Micco","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1111\/acel.12562-BIB0035|acel12562-cit-0035","doi-asserted-by":"crossref","first-page":"16180","DOI":"10.1016\/S0021-9258(17)33990-X","article-title":"Regulation of two E2F-related genes in presenescent and senescent human fibroblasts","volume":"269","author":"Dimri","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1111\/acel.12562-BIB0036|acel12562-cit-0036","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in\u00a0vivo","volume":"92","author":"Dimri","year":"1995","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1111\/acel.12562-BIB0037|acel12562-cit-0037","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1159\/000109185","article-title":"Replicative senescence, aging and growth-regulatory transcription factors","volume":"5","author":"Dimri","year":"1996","journal-title":"Biol. Signals"},{"key":"10.1111\/acel.12562-BIB0038|acel12562-cit-0038","doi-asserted-by":"crossref","first-page":"8695","DOI":"10.1074\/jbc.275.12.8695","article-title":"Cbfa1 is a positive regulatory factor in chondrocyte maturation","volume":"275","author":"Enomoto","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1111\/acel.12562-BIB0039|acel12562-cit-0039","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0002-9440(10)63808-4","article-title":"Vascular endothelial growth factor isoforms and their receptors are expressed in human osteoarthritic cartilage","volume":"162","author":"Enomoto","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1111\/acel.12562-BIB0040|acel12562-cit-0040","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.exger.2005.04.010","article-title":"Cellular senescence in\u00a0vivo: its relevance in ageing and cardiovascular disease","volume":"40","author":"Erusalimsky","year":"2005","journal-title":"Exp. Gerontol."},{"key":"10.1111\/acel.12562-BIB0041|acel12562-cit-0041","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1002\/art.24472","article-title":"Methylation status of CpG islands in the promoter regions of signature genes during chondrogenesis of human synovium-derived mesenchymal stem cells","volume":"60","author":"Ezura","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1111\/acel.12562-BIB0042|acel12562-cit-0042","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1002\/jbmr.2892","article-title":"Identification of senescent cells in the bone microenvironment","volume":"31","author":"Farr","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"10.1111\/acel.12562-BIB0043|acel12562-cit-0043","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/301089a0","article-title":"Hypomethylation distinguishes genes of some human cancers from their normal counterparts","volume":"301","author":"Feinberg","year":"1983","journal-title":"Nature"},{"key":"10.1111\/acel.12562-BIB0044|acel12562-cit-0044","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI21625","article-title":"Increased oxidative stress in obesity and its impact on metabolic syndrome","volume":"114","author":"Furukawa","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1111\/acel.12562-BIB0045|acel12562-cit-0045","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/1756-185X.12096","article-title":"Correlation between senescence-associated beta-galactosidase expression in articular cartilage and disease severity of patients with knee osteoarthritis","volume":"19","author":"Gao","year":"2016","journal-title":"Int. J. Rheum. Dis."},{"key":"10.1111\/acel.12562-BIB0046|acel12562-cit-0046","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nature16187","article-title":"Autophagy maintains stemness by preventing senescence","volume":"529","author":"Garc\u00eda-Prat","year":"2016","journal-title":"Nature"},{"key":"10.1111\/acel.12562-BIB0047|acel12562-cit-0047","doi-asserted-by":"crossref","first-page":"321","DOI":"10.7326\/0003-4819-133-5-200009050-00007","article-title":"Joint injury in young adults and risk for subsequent knee and hip osteoarthritis","volume":"133","author":"Gelber","year":"2000","journal-title":"Ann. Intern. Med."},{"key":"10.1111\/acel.12562-BIB0048|acel12562-cit-0048","doi-asserted-by":"crossref","first-page":"R193","DOI":"10.1186\/ar756","article-title":"Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis","volume":"5","author":"Giatromanolaki","year":"2003","journal-title":"Arthritis. Res. Ther."},{"key":"10.1111\/acel.12562-BIB0049|acel12562-cit-0049","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1038\/onc.2009.95","article-title":"Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice","volume":"28","author":"Goel","year":"2009","journal-title":"Oncogene"},{"key":"10.1111\/acel.12562-BIB0050|acel12562-cit-0050","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4161\/bioa.29668","article-title":"Therapies for sarcopenia and regeneration of old skeletal muscles: more a case of old tissue architecture than old stem cells","volume":"4","author":"Grounds","year":"2014","journal-title":"Bioarchitecture"},{"key":"10.1111\/acel.12562-BIB0051|acel12562-cit-0051","doi-asserted-by":"crossref","first-page":"R12","DOI":"10.1186\/ar3687","article-title":"The distribution pattern of critically short telomeres in human osteoarthritic knees","volume":"14","author":"Harbo","year":"2012","journal-title":"Arthritis. Res. Ther."},{"key":"10.1111\/acel.12562-BIB0052|acel12562-cit-0052","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.mad.2013.07.002","article-title":"The relationship between ultra-short telomeres, aging of articular cartilage and the development of human hip osteoarthritis","volume":"134","author":"Harbo","year":"2013","journal-title":"Mech. Ageing Dev."},{"key":"10.1111\/acel.12562-BIB0053|acel12562-cit-0053","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1053\/joca.2001.0505","article-title":"Development and regulation of osteophyte formation during experimental osteoarthritis","volume":"10","author":"Hashimoto","year":"2002","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1111\/acel.12562-BIB0054|acel12562-cit-0054","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1002\/art.24882","article-title":"DNA De-methylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes","volume":"60","author":"Hashimoto","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1111\/acel.12562-BIB0055|acel12562-cit-0055","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1002\/art.20124","article-title":"The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model","volume":"50","author":"Hayami","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1111\/acel.12562-BIB0056|acel12562-cit-0056","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0014-4827(61)90192-6","article-title":"The serial cultivation of human diploid cell strains","volume":"25","author":"Hayflick","year":"1961","journal-title":"Exp. Cell Res."},{"key":"10.1111\/acel.12562-BIB0057|acel12562-cit-0057","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S1097-2765(04)00256-4","article-title":"Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)","volume":"14","author":"Herbig","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1111\/acel.12562-BIB0058|acel12562-cit-0058","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mad.2006.11.008","article-title":"Accumulation of senescent cells in mitotic tissue of aging primates","volume":"128","author":"Jeyapalan","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"10.1111\/acel.12562-BIB0059|acel12562-cit-0059","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1002\/art.22041","article-title":"Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability","volume":"54","author":"Kamekura","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1111\/acel.12562-BIB0060|acel12562-cit-0060","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/01.ATV.0000058402.34138.11","article-title":"Obesity and systemic oxidative stress","volume":"23","author":"Keaney","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1111\/acel.12562-BIB0061|acel12562-cit-0061","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1089\/ten.tea.2014.0535","article-title":"Differential effects of culture senescence and mechanical stimulation on the proliferation and leiomyogenic differentiation of MSC from different sources: implications for engineering vascular grafts","volume":"21","author":"Koobatian","year":"2015","journal-title":"Tissue Eng. Part A"},{"key":"10.1111\/acel.12562-BIB0062|acel12562-cit-0062","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1172\/JCI22475","article-title":"Ink4a\/Arf expression is a biomarker of aging","volume":"114","author":"Krishnamurthy","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1111\/acel.12562-BIB0063|acel12562-cit-0063","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2008.06.049","article-title":"Senescence of activated stellate cells limits liver fibrosis","volume":"134","author":"Krizhanovsky","year":"2008","journal-title":"Cell"},{"key":"10.1111\/acel.12562-BIB0064|acel12562-cit-0064","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrc2560","article-title":"Senescence-messaging secretome: SMS-ing cellular stress","volume":"9","author":"Kuilman","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1111\/acel.12562-BIB0065|acel12562-cit-0065","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.cell.2008.03.039","article-title":"Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network","volume":"133","author":"Kuilman","year":"2008","journal-title":"Cell"},{"key":"10.1111\/acel.12562-BIB0066|acel12562-cit-0066","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1128\/MCB.17.4.2336","article-title":"SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene","volume":"17","author":"Lefebvre","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1111\/acel.12562-BIB0067|acel12562-cit-0067","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/nm.2050","article-title":"Synovial fibroblasts spread rheumatoid arthritis to unaffected joints","volume":"15","author":"Lefevre","year":"2009","journal-title":"Nat. Med."},{"key":"10.1111\/acel.12562-BIB0068|acel12562-cit-0068","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1002\/art.25002","article-title":"Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development","volume":"60","author":"Little","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1111\/acel.12562-BIB0069|acel12562-cit-0069","doi-asserted-by":"crossref","first-page":"431","DOI":"10.18632\/aging.100467","article-title":"Replicatively senescent cells are arrested in G1 and G2 phases","volume":"4","author":"Mao","year":"2012","journal-title":"Aging"},{"key":"10.1111\/acel.12562-BIB0070|acel12562-cit-0070","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/art.1780350715","article-title":"Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy","volume":"35","author":"Mark","year":"1992","journal-title":"Arthritis Rheum."},{"key":"10.1111\/acel.12562-BIB0071|acel12562-cit-0071","doi-asserted-by":"crossref","first-page":"B172","DOI":"10.1093\/gerona\/56.4.B172","article-title":"Telomere erosion and senescence in human articular cartilage chondrocytes","volume":"56","author":"Martin","year":"2001","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1111\/acel.12562-BIB0072|acel12562-cit-0072","first-page":"479","article-title":"Post-traumatic osteoarthritis: the role of accelerated chondrocyte senescence","volume":"41","author":"Martin","year":"2004a","journal-title":"Biorheology"},{"key":"10.1111\/acel.12562-BIB0073|acel12562-cit-0073","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/gerona\/59.4.B324","article-title":"Effects of oxidative damage and telomerase activity on human articular cartilage chondrocyte senescence","volume":"59","author":"Martin","year":"2004b","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1111\/acel.12562-BIB0074|acel12562-cit-0074","first-page":"991","article-title":"Aberrant deoxyribonucleic acid methylation in human thyroid tumors","volume":"77","author":"Matsuo","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1111\/acel.12562-BIB0075|acel12562-cit-0075","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nature03890","article-title":"BRAFE600-associated senescence-like cell cycle arrest of human naevi","volume":"436","author":"Michaloglou","year":"2005","journal-title":"Nature"},{"key":"10.1111\/acel.12562-BIB0076|acel12562-cit-0076","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1161\/01.CIR.0000013836.85741.17","article-title":"Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction","volume":"105","author":"Minamino","year":"2002","journal-title":"Circulation"},{"key":"10.1111\/acel.12562-BIB0077|acel12562-cit-0077","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/nm0905-920","article-title":"Senescence comes of age","volume":"11","author":"Narita","year":"2005","journal-title":"Nat. Med."},{"key":"10.1111\/acel.12562-BIB0078|acel12562-cit-0078","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1126\/science.1205407","article-title":"Spatial coupling of mTOR and autophagy augments secretory phenotypes","volume":"332","author":"Narita","year":"2011","journal-title":"Science"},{"key":"10.1111\/acel.12562-BIB0079|acel12562-cit-0079","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1172\/JCI10564","article-title":"Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice","volume":"107","author":"Neuhold","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1111\/acel.12562-BIB0080|acel12562-cit-0080","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1136\/ard.2009.119776","article-title":"Synovial tissue hypoxia and inflammation in\u00a0vivo","volume":"69","author":"Ng","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1111\/acel.12562-BIB0081|acel12562-cit-0081","doi-asserted-by":"crossref","first-page":"5210","DOI":"10.1128\/MCB.16.9.5210","article-title":"Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent","volume":"16","author":"Ogryzko","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1111\/acel.12562-BIB0082|acel12562-cit-0082","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1002\/art.20461","article-title":"Cooperation of Ras- and c-Myc-dependent pathways in regulating the growth and invasiveness of synovial fibroblasts in rheumatoid arthritis","volume":"50","author":"Pap","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1111\/acel.12562-BIB0083|acel12562-cit-0083","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1136\/ard.60.11.1070","article-title":"Vascular endothelial growth factor in articular cartilage of healthy and osteoarthritic human knee joints","volume":"60","author":"Pfander","year":"2001","journal-title":"Ann. Rheum. Dis."},{"key":"10.1111\/acel.12562-BIB0084|acel12562-cit-0084","doi-asserted-by":"crossref","first-page":"R58","DOI":"10.1186\/ar4494","article-title":"p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis","volume":"16","author":"Philipot","year":"2014","journal-title":"Arthritis. Res. Ther."},{"key":"10.1111\/acel.12562-BIB0085|acel12562-cit-0085","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1474-9728.2002.00008.x","article-title":"The role of chondrocyte senescence in osteoarthritis","volume":"1","author":"Price","year":"2002","journal-title":"Aging Cell"},{"key":"10.1111\/acel.12562-BIB0086|acel12562-cit-0086","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1002\/art.21300","article-title":"Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions","volume":"52","author":"Roach","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1111\/acel.12562-BIB0087|acel12562-cit-0087","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/ncb1909","article-title":"Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion","volume":"11","author":"Rodier","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1111\/acel.12562-BIB0088|acel12562-cit-0088","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.2337\/db15-0291","article-title":"Exercise prevents diet-induced cellular senescence in adipose tissue","volume":"65","author":"Schafer","year":"2016","journal-title":"Diabetes"},{"key":"10.1111\/acel.12562-BIB0089|acel12562-cit-0089","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0092-8674(00)81902-9","article-title":"Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a","volume":"88","author":"Serrano","year":"1997","journal-title":"Cell"},{"key":"10.1111\/acel.12562-BIB0090|acel12562-cit-0090","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0092-8674(00)00046-5","article-title":"Cellular senescence","volume":"102","author":"Sherr","year":"2000","journal-title":"Cell"},{"key":"10.1111\/acel.12562-BIB0091|acel12562-cit-0091","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/art.1780401120","article-title":"Osteoarthritic lesions. Involvement of three different collagenases","volume":"40","author":"Shlopov","year":"1997","journal-title":"Arthritis Rheum."},{"key":"10.1111\/acel.12562-BIB0092|acel12562-cit-0092","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.joca.2005.04.014","article-title":"A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis","volume":"13","author":"Srikanth","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1111\/acel.12562-BIB0093|acel12562-cit-0093","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1474-9726.2010.00608.x","article-title":"Fat tissue, aging, and cellular senescence","volume":"9","author":"Tchkonia","year":"2010","journal-title":"Aging Cell"},{"key":"10.1111\/acel.12562-BIB0094|acel12562-cit-0094","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0531-5565(03)00114-1","article-title":"Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis","volume":"38","author":"Terman","year":"2003","journal-title":"Exp. Gerontol."},{"key":"10.1111\/acel.12562-BIB0095|acel12562-cit-0095","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/hep.27140","article-title":"Suppression of autophagy during liver regeneration impairs energy charge and hepatocyte senescence in mice","volume":"60","author":"Toshima","year":"2014","journal-title":"Hepatology"},{"key":"10.1111\/acel.12562-BIB0096|acel12562-cit-0096","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/j.1474-9726.2012.00837.x","article-title":"The number of p16INK4a positive cells in human skin reflects biological age","volume":"11","author":"Waaijer","year":"2012","journal-title":"Aging Cell"},{"key":"10.1111\/acel.12562-BIB0097|acel12562-cit-0097","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0092-8674(95)90319-4","article-title":"Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer","volume":"82","author":"Wind","year":"1995","journal-title":"Cell"},{"key":"10.1111\/acel.12562-BIB0098|acel12562-cit-0098","doi-asserted-by":"crossref","first-page":"425","DOI":"10.18632\/aging.100038","article-title":"Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy","volume":"1","author":"Wu","year":"2009","journal-title":"Aging"},{"key":"10.1111\/acel.12562-BIB0099|acel12562-cit-0099","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/rheumatology\/kev312","article-title":"Bromodomain and extra-terminal domain bromodomain inhibition prevents synovial inflammation via blocking IkappaB kinase-dependent NF-kappaB activation in rheumatoid fibroblast-like synoviocytes","volume":"55","author":"Xiao","year":"2016","journal-title":"Rheumatology"},{"key":"10.1111\/acel.12562-BIB0100|acel12562-cit-0100","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glw154","article-title":"Transplanted senescent cells induce an osteoarthritis-like condition in mice","author":"Xu","year":"2016","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1111\/acel.12562-BIB0101|acel12562-cit-0101","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1083\/jcb.153.1.35","article-title":"TGF-beta\/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage","volume":"153","author":"Yang","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1111\/acel.12562-BIB0102|acel12562-cit-0102","doi-asserted-by":"crossref","first-page":"19610","DOI":"10.1074\/jbc.M009470200","article-title":"DNA methyltransferase inhibition in normal human fibroblasts induces a p21-dependent cell cycle withdrawal","volume":"276","author":"Young","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1111\/acel.12562-BIB0103|acel12562-cit-0103","doi-asserted-by":"crossref","first-page":"R380","DOI":"10.1186\/ar1499","article-title":"Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function","volume":"7","author":"Yudoh","year":"2005","journal-title":"Arthritis. Res. Ther."},{"key":"10.1111\/acel.12562-BIB0104|acel12562-cit-0104","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.imlet.2015.05.016","article-title":"Targeting bromodomain-containing protein 4 (BRD4) benefits rheumatoid arthritis","volume":"166","author":"Zhang","year":"2015","journal-title":"Immunol. Lett."},{"key":"10.1111\/acel.12562-BIB0105|acel12562-cit-0105","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1083\/jcb.200211089","article-title":"Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in\u00a0vivo","volume":"162","author":"Zheng","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1111\/acel.12562-BIB0106|acel12562-cit-0106","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/rheumatology\/keh127","article-title":"Recovery of function in osteoarthritic chondrocytes induced by p16INK4a-specific siRNA in\u00a0vitro","volume":"43","author":"Zhou","year":"2004","journal-title":"Rheumatology"},{"key":"10.1111\/acel.12562-BIB0107|acel12562-cit-0107","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/acel.12445","article-title":"Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors","volume":"15","author":"Zhu","year":"2015a","journal-title":"Aging Cell"},{"key":"10.1111\/acel.12562-BIB0108|acel12562-cit-0108","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/acel.12344","article-title":"The Achilles\u2019 heel of senescent cells: from transcriptome to senolytic drugs","volume":"14","author":"Zhu","year":"2015b","journal-title":"Aging Cell"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facel.12562","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/acel.12562\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T16:37:51Z","timestamp":1658507871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.12562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,26]]},"references-count":108,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"URL":"https:\/\/doi.org\/10.1111\/acel.12562","archive":["Portico"],"relation":{},"ISSN":["1474-9718"],"issn-type":[{"value":"1474-9718","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,26]]}}}