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We have recently reported that the inhibition of G9a\/<jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content> complex promotes long\u2010term potentiation (<jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content>) and its associative mechanisms such as synaptic tagging and capture (<jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content>). However, the role of this complex in plasticity impairments remains elusive. Here, we investigated the involvement of G9a\/<jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content> complex in alleviating the effects of soluble Amyloid\u2010\u03b2 1\u201042 oligomers (<jats:styled-content style=\"fixed-case\">oA<\/jats:styled-content>\u03b2) on neuronal plasticity and associativity in the <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>1 region of acute hippocampal slices from 5\u2010 to 7\u2010week\u2010old male Wistar rats. Our findings demonstrate that the regulation of G9a\/<jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content> complex by inhibiting its catalytic activity reverses the amyloid\u2010\u03b2 oligomer\u2010induced deficits in late\u2010<jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content>. This is achieved by releasing the transcription repression of the brain\u2010derived neurotrophic factor (<jats:italic>Bdnf<\/jats:italic>) gene. The catalytic inhibition of G9a\/<jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content> complex leads to the upregulation of <jats:italic>Bdnf<\/jats:italic> expression in the slices treated with <jats:styled-content style=\"fixed-case\">oA<\/jats:styled-content>\u03b2. This further ensures the availability of <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> that subsequently binds its receptor tyrosine kinase B (TrkB) and maintains the late\u2010<jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content>. Furthermore, the capture of <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> by weakly activated synapses re\u2010establishes <jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content>. Our findings regarding the reinstatement of functional plasticity and associativity in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010like conditions provide the first evidence for the role of G9a\/<jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content> complex in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. We propose G9a\/<jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content> complex as the possible target for preventing <jats:styled-content style=\"fixed-case\">oA<\/jats:styled-content>\u03b2\u2010induced plasticity deficits in hippocampal neurons.<\/jats:p>","DOI":"10.1111\/acel.12634","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T10:26:37Z","timestamp":1498818397000},"page":"1062-1072","source":"Crossref","is-referenced-by-count":55,"title":["Epigenetic regulation by G9a\/<scp>GLP<\/scp> complex ameliorates amyloid\u2010beta 1\u201042 induced deficits in long\u2010term plasticity and synaptic tagging\/capture in hippocampal pyramidal neurons"],"prefix":"10.1111","volume":"16","author":[{"given":"Mahima","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Physiology Yong Loo Lin School of Medicine National University of Singapore Block MD9, 2 Medical Drive Singapore 117 597 Singapore"},{"name":"Neurobiology\/Aging Program Life Sciences Institute (LSI) National University of Singapore #04\u201044, 28 Medical Drive Singapore 117 456 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Dierkes","sequence":"additional","affiliation":[{"name":"Department of Physiology Yong Loo Lin School of Medicine National University of Singapore Block MD9, 2 Medical Drive Singapore 117 597 Singapore"},{"name":"Institute of Innate Immunity Biomedical Centre University hospital Bonn Sigmund\u2010Freud\u2010Str. 25 Bonn 53127 Germany"},{"name":"Division of Cellular Neurobiology Zoological Institute Technical University Braunschweig Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreedharan","family":"Sajikumar","sequence":"additional","affiliation":[{"name":"Department of Physiology Yong Loo Lin School of Medicine National University of Singapore Block MD9, 2 Medical Drive Singapore 117 597 Singapore"},{"name":"Neurobiology\/Aging Program Life Sciences Institute (LSI) National University of Singapore #04\u201044, 28 Medical Drive Singapore 117 456 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.05.012"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2014.08.023"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002389"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002387"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161226236"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1012851108"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3233\/JAD-132285","article-title":"Age\u2010dependent increment of hydroxymethylation in the brain cortex in the triple\u2010transgenic mouse model of Alzheimer's disease","volume":"41","author":"Cadena\u2010del\u2010Castillo C","year":"2014","journal-title":"J. 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