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Genomewide association studies have linked <jats:italic><jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>2B1<\/jats:italic>, the gene for the plasma membrane calcium <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>ase 1 (<jats:styled-content style=\"fixed-case\">PMCA<\/jats:styled-content>1), to blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) and hypertension. Here, we present the effects of reduction in the expression of <jats:styled-content style=\"fixed-case\">PMCA<\/jats:styled-content>1 on <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and small artery structure and function when combined with advancing age. Heterozygous <jats:styled-content style=\"fixed-case\">PMCA<\/jats:styled-content>1 null mice (<jats:styled-content style=\"fixed-case\">PMCA<\/jats:styled-content>1<jats:sup>Ht<\/jats:sup>) were generated and conscious <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> was measured at 6 to 18\u00a0months of age. Passive and active properties of isolated small mesenteric arteries were examined by pressure myography. <jats:styled-content style=\"fixed-case\">PMCA<\/jats:styled-content>1<jats:sup>Ht<\/jats:sup> mice exhibited normal <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> at 6 and 9\u00a0months of age but developed significantly elevated <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> when compared to age\u2010matched wild\u2010type controls at \u226512\u00a0months of age. Decreased lumen diameter, increased wall thickness and increased wall:lumen ratio were observed in small mesenteric arteries from animals 9\u00a0months of age and older, indicative of eutrophic remodelling. Increases in mesenteric artery intrinsic tone and global intracellular calcium were evident in animals at both 6 and 18\u00a0months of age. Thus, decreased expression of <jats:styled-content style=\"fixed-case\">PMCA<\/jats:styled-content>1 is associated with increased <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> when combined with advancing age. Changes in arterial structure precede the elevation of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>. Pathways involving <jats:styled-content style=\"fixed-case\">PMCA<\/jats:styled-content>1 may be a novel target for <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> regulation in the elderly.<\/jats:p>","DOI":"10.1111\/acel.12637","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T04:09:09Z","timestamp":1502338149000},"page":"1104-1113","source":"Crossref","is-referenced-by-count":15,"title":["Reduced expression of <scp>PMCA<\/scp>1 is associated with increased blood pressure with age which is preceded by remodelling of resistance arteries"],"prefix":"10.1111","volume":"16","author":[{"given":"Robert","family":"Little","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Sciences Manchester Academic Health Science Centre The University of Manchester AV Hill Building Manchester M13 9PT UK"},{"name":"School of Food Science and Nutrition The University of Leeds Leeds LS2 9JT 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UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Njegic","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Sciences Manchester Academic Health Science Centre The University of Manchester AV Hill Building Manchester M13 9PT UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sathishkumar","family":"Kurusamy","sequence":"additional","affiliation":[{"name":"Research Institute in Healthcare Science School of Pharmacy University of Wolverhampton Wolverhampton WV1 1LY UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukhpal","family":"Prehar","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Sciences Manchester Academic Health Science Centre The University of Manchester AV Hill Building Manchester M13 9PT UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel L.","family":"Armesilla","sequence":"additional","affiliation":[{"name":"Research Institute 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