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We demonstrate here that autophagy is significantly reduced in aged <jats:styled-content style=\"fixed-case\">BMMSC<\/jats:styled-content>s compared with young <jats:styled-content style=\"fixed-case\">BMMSC<\/jats:styled-content>s. The autophagy inhibitor 3\u2010methyladenine (3\u2010<jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>) could turn young <jats:styled-content style=\"fixed-case\">BMMSC<\/jats:styled-content>s into a relatively aged state by reducing their osteogenic differentiation and proliferation capacity and enhancing their adipogenic differentiation capacity. Accordingly, the autophagy activator rapamycin could restore the biological properties of aged <jats:styled-content style=\"fixed-case\">BMMSC<\/jats:styled-content>s by increasing osteogenic differentiation and proliferation capacity and decreasing adipogenic differentiation capacity. Possible underlying mechanisms were explored, and the analysis revealed that autophagy could affect reactive oxygen species and p53 levels, thus regulating biological properties of <jats:styled-content style=\"fixed-case\">BMMSC<\/jats:styled-content>s. In an in\u00a0vivo study, we found that activation of autophagy restored bone loss in aged mice. In conclusion, our results suggest that autophagy plays a pivotal role in the aging of <jats:styled-content style=\"fixed-case\">BMMSC<\/jats:styled-content>s, and activation of autophagy could partially reverse this aging and may represent a potential therapeutic avenue to clinically treat age\u2010related bone loss.<\/jats:p>","DOI":"10.1111\/acel.12709","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T08:58:42Z","timestamp":1512550722000},"source":"Crossref","is-referenced-by-count":315,"title":["Autophagy controls mesenchymal stem cell properties and senescence during bone aging"],"prefix":"10.1111","volume":"17","author":[{"given":"Yang","family":"Ma","sequence":"first","affiliation":[{"name":"State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi International Joint Research Center for Oral Diseases Center for Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an Shaanxi China"},{"name":"Department of Craniofacial Development and Stem Cell Biology Dental Institute Kings College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Qi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi International Joint Research Center for Oral Diseases Center for Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"An","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi International Joint Research Center for Oral Diseases Center for Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an Shaanxi China"},{"name":"State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi International Joint Research Center for Oral Diseases Department of Periodontology School of Stomatology The Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology &amp; 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