{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:12:04Z","timestamp":1790471524541,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,18]],"date-time":"2018-02-18T00:00:00Z","timestamp":1518912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,2,18]],"date-time":"2018-02-18T00:00:00Z","timestamp":1518912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI102838"],"award-info":[{"award-number":["AI102838"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI117739"],"award-info":[{"award-number":["AI117739"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Summary<\/jats:title>\n \n As women age, susceptibility to systemic and genital infections increases. Tissue\u2010resident memory T cells (\n TRM<\/jats:styled-content>\n s) are\n CD<\/jats:styled-content>\n 103\n +<\/jats:sup>\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n long\u2010lived lymphocytes that provide critical mucosal immune protection. Mucosal dendritic cells (\n DC<\/jats:styled-content>\n s) are known to induce\n CD<\/jats:styled-content>\n 103 expression on\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n T cells. While\n CD<\/jats:styled-content>\n 103\n +<\/jats:sup>\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n T cells are found throughout the female reproductive tract (\n FRT<\/jats:styled-content>\n ), the extent to which aging impacts their presence and induction by\n DC<\/jats:styled-content>\n s remains unknown. Using hysterectomy tissues, we found that endometrial\n CD<\/jats:styled-content>\n 103\n +<\/jats:sup>\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n T cells were increased in postmenopausal compared to premenopausal women. Endometrial\n DC<\/jats:styled-content>\n s from postmenopausal women were significantly more effective at inducing\n CD<\/jats:styled-content>\n 103 expression on allogeneic na\u00efve\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n T cells than\n DC<\/jats:styled-content>\n s from premenopausal women;\n CD<\/jats:styled-content>\n 103 upregulation was mediated through membrane\u2010bound\n TGF<\/jats:styled-content>\n \u03b2 signaling. In contrast, cervical\n CD<\/jats:styled-content>\n 103\n +<\/jats:sup>\n T cells and\n DC<\/jats:styled-content>\n numbers declined in postmenopausal women with age. Decreases in\n DC<\/jats:styled-content>\n s correlated with decreased\n CD<\/jats:styled-content>\n 103\n +<\/jats:sup>\n T cells in endocervix, but not ectocervix. Our findings demonstrate a previously unrecognized compartmentalization of\n TRM<\/jats:styled-content>\n s in the\n FRT<\/jats:styled-content>\n of postmenopausal women, with loss of\n TRM<\/jats:styled-content>\n s and\n DC<\/jats:styled-content>\n s in the cervix with aging, and increased\n TRM<\/jats:styled-content>\n s and\n DC<\/jats:styled-content>\n induction capacity in the endometrium. These findings are relevant to understanding immune protection in the\n FRT<\/jats:styled-content>\n and to the design of vaccines for women of all ages.\n <\/jats:p>","DOI":"10.1111\/acel.12733","type":"journal-article","created":{"date-parts":[[2018,2,18]],"date-time":"2018-02-18T00:07:21Z","timestamp":1518912441000},"source":"Crossref","is-referenced-by-count":50,"title":["Aging impacts\n CD<\/scp>\n 103\n +<\/sup>\n CD<\/scp>\n 8\n +<\/sup>\n T cell presence and induction by dendritic cells in the genital tract"],"prefix":"10.1111","volume":"17","author":[{"given":"Marta","family":"Rodriguez\u2010Garcia","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Geisel School of Medicine at Dartmouth Lebanon NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared M.","family":"Fortier","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Geisel School of Medicine at Dartmouth Lebanon NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona D.","family":"Barr","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Geisel School of Medicine at Dartmouth Lebanon NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R.","family":"Wira","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Geisel School of Medicine at Dartmouth Lebanon NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200402"},{"key":"e_1_2_8_3_1","volume-title":"Surveillance Supplemental Report 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