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Aging is the main risk factor for Alzheimer's disease that cannot be explained by amyloid hypothesis. To evaluate how aging and Alzheimer's disease are intrinsically interwoven with each other, we review and summarize evidence from molecular, cellular, and system level. In particular, we focus on study designs, treatments, or interventions in Alzheimer's disease that could also be insightful in aging and vice versa.<\/jats:p>","DOI":"10.1111\/acel.12802","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T06:06:13Z","timestamp":1530511573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":288,"title":["Aging and Alzheimer\u2019s disease: Comparison and associations from molecular to system level"],"prefix":"10.1111","volume":"17","author":[{"given":"Xian","family":"Xia","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Computational Biology, CAS\u2010MPG Partner Institute for Computational Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences Chinese Academy of Sciences   Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanlong","family":"Jiang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Computational Biology, CAS\u2010MPG Partner Institute for Computational Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences Chinese Academy of Sciences   Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"McDermott","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Computational Biology, CAS\u2010MPG Partner Institute for Computational Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences Chinese Academy of Sciences   Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Dong J.","family":"Han","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Computational Biology, CAS\u2010MPG Partner Institute for Computational Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences Chinese Academy of Sciences   Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2011.0252"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-203009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb01647.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2008.01934.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.10.016"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2008.0827"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.185"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah5143"},{"key":"e_1_2_8_10_1","first-page":"797","article-title":"The Mental Activity and eXercise (MAX) trial: A randomized controlled trial to enhance cognitive function in older adults","volume":"173","author":"Barnes D. 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