{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:32:36Z","timestamp":1790854356492,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:00:00Z","timestamp":1544572800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:00:00Z","timestamp":1544572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["BC110089"],"award-info":[{"award-number":["BC110089"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG058714"],"award-info":[{"award-number":["AG058714"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM094513"],"award-info":[{"award-number":["GM094513"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16PRE27510016"],"award-info":[{"award-number":["16PRE27510016"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH092769"],"award-info":[{"award-number":["MH092769"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hutchinson\u2010Gilford Progeria Syndrome (HGPS) is a devastating premature aging disease. Mouse models have been instrumental for understanding HGPS mechanisms and for testing therapies, which to date have had only marginal benefits in mice and patients. Barriers to developing effective therapies include the unknown etiology of progeria mice early death, seemingly unrelated to the reported atherosclerosis contributing to HGPS patient mortality, and mice not recapitulating the severity of human disease. Here, we show that progeria mice die from starvation and cachexia. Switching progeria mice approaching death from regular diet to high\u2010fat diet (HFD) rescues early lethality and ameliorates morbidity. Critically, feeding the mice only HFD delays aging and nearly doubles lifespan, which is the greatest lifespan extension recorded in progeria mice. The extended lifespan allows for progeria mice to develop degenerative aging pathologies of a severity that emulates the human disease. We propose that starvation and cachexia greatly influence progeria phenotypes and that nutritional\/nutraceutical strategies might help modulate disease progression. Importantly, progeria mice on HFD provide a more clinically relevant animal model to study mechanisms of HGPS pathology and to test therapies.<\/jats:p>","DOI":"10.1111\/acel.12852","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T11:41:12Z","timestamp":1544614872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Doubled lifespan and patient\u2010like pathologies in progeria mice fed high\u2010fat diet"],"prefix":"10.1111","volume":"18","author":[{"given":"Ray","family":"Kreienkamp","sequence":"first","affiliation":[{"name":"Edward A. Doisy Department of Biochemistry and Molecular Biology St Louis University School of Medicine St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrielle","family":"Billon","sequence":"additional","affiliation":[{"name":"Center for Clinical Pharmacology Washington University School of Medicine and St. Louis College of Pharmacy St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Bedia\u2010Diaz","sequence":"additional","affiliation":[{"name":"Edward A. Doisy Department of Biochemistry and Molecular Biology St Louis University School of Medicine St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn J.","family":"Albert","sequence":"additional","affiliation":[{"name":"Edward A. Doisy Department of Biochemistry and Molecular Biology St Louis University School of Medicine St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zacharie","family":"Toth","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery St Louis University School of Medicine St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology St Louis University School of Medicine St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"McBride\u2010Gagyi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery St Louis University School of Medicine St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Ford","sequence":"additional","affiliation":[{"name":"Edward A. Doisy Department of Biochemistry and Molecular Biology St Louis University School of Medicine St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Baldan","sequence":"additional","affiliation":[{"name":"Edward A. Doisy Department of Biochemistry and Molecular Biology St Louis University School of Medicine St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Burris","sequence":"additional","affiliation":[{"name":"Center for Clinical Pharmacology Washington University School of Medicine and St. Louis College of Pharmacy St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Gonzalo","sequence":"additional","affiliation":[{"name":"Edward A. Doisy Department of Biochemistry and Molecular Biology St Louis University School of Medicine St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3829"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12142"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.09.027"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002346"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807840105"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022965"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3600143"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124875"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12300"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2015.05.007"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.06.007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202529109"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.008285"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1356"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9065"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.01.090"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1252651"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.067595"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"e1712","DOI":"10.1016\/j.cell.2016.11.052","article-title":"In vivo amelioration of age\u2010associated hallmarks by partial reprogramming","volume":"167","author":"Ocampo A.","year":"2016","journal-title":"Cell"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.197954.112"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002847"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4939"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12070"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04492-0"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2011.00743.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.067587"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.10.005"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.05.029"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.09.010"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2007.03.008"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-62702-5.00018-4"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000571"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307680110"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/110.12.2490"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.3845"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.07.011"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.12852","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.12852","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.12852","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.12852","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T23:23:55Z","timestamp":1694733835000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.12852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,12]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/acel.12852"],"URL":"https:\/\/doi.org\/10.1111\/acel.12852","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,12]]},"assertion":[{"value":"2018-08-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12852"}}