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Cardiac failure is the primary reason for hospitalization of the elderly (65+ years). The elderly are also increasingly susceptible to developing chronic bacterial infections due to aging associated immune abnormalities. Since bacterial infections compound the rates of cardiac failure in the elderly, and this phenomenon is not entirely understood, the interplay between the immune system and cardiovascular function in the elderly is of great interest. Using <jats:italic>Mycobacterium avium,<\/jats:italic> an opportunistic pathogen, we investigated the effect of mycobacteria on cardiac function in aged mice. Young (2\u20133\u00a0months) and old (18\u201320\u00a0months) C57BL\/6 mice were intranasally infected with <jats:italic>M.\u00a0avium<\/jats:italic> strain 104, and we compared the bacterial burden, immune status, cardiac electrical activity, pathology, and function of infected mice against uninfected age\u2010matched controls. Herein, we show that biological aging may predispose old mice infected with <jats:italic>M.\u00a0avium<\/jats:italic> to mycobacterial dissemination into the heart tissue and this leads to cardiac dysfunction. <jats:italic>M.\u00a0avium<\/jats:italic> infected old mice had significant dysrhythmia, cardiac hypertrophy, increased recruitment of CD45<jats:sup>+<\/jats:sup> leukocytes, cardiac fibrosis, and increased expression of inflammatory genes in isolated heart tissue. This is the first study to report the effect of mycobacteria on cardiac function in an aged model. Our findings are critical to understanding how nontuberculous mycobacterium (NTM) and other mycobacterial infections contribute to cardiac dysfunction in the elderly population.<\/jats:p>","DOI":"10.1111\/acel.12926","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T02:56:40Z","timestamp":1551754600000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Nontuberculous mycobacterium <i>M.\u00a0avium<\/i> infection predisposes aged mice to cardiac abnormalities and inflammation"],"prefix":"10.1111","volume":"18","author":[{"given":"Colwyn A.","family":"Headley","sequence":"first","affiliation":[{"name":"Department of Microbial Infection and Immunity, College of Medicine The Ohio State University Wexner Medical Center Columbus Ohio"},{"name":"Texas Biomedical Research Institute 8715 W. 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