{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:43:17Z","timestamp":1790642597500,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-341566"],"award-info":[{"award-number":["MOP-341566"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-130469"],"award-info":[{"award-number":["MOP-130469"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Some studies show eliminating senescent cells rejuvenate aged mice and attenuate deleterious effects of chemotherapy. Nevertheless, it remains unclear whether senescence affects immune cell function. We provide evidence that exposure of mice to ionizing radiation (IR) promotes the senescent\u2010associated secretory phenotype (SASP) and expression of p16\n                    <jats:sup>INK4a<\/jats:sup>\n                    in splenic cell populations. We observe splenic T cells exhibit a reduced proliferative response when cultured with allogenic cells in vitro and following viral infection in vivo. Using p16\u20103MR mice that allow elimination of p16\n                    <jats:sup>INK4a<\/jats:sup>\n                    \u2010positive cells with exposure to ganciclovir, we show that impaired T\u2010cell proliferation is partially reversed, mechanistically dependent on p16\n                    <jats:sup>INK4a<\/jats:sup>\n                    expression and the SASP. Moreover, we found macrophages isolated from irradiated spleens to have a reduced phagocytosis activity in vitro, a defect also restored by the elimination of p16\n                    <jats:sup>INK4a<\/jats:sup>\n                    expression. Our results provide molecular insight on how senescence\u2010inducing IR promotes loss of immune cell fitness, which suggest senolytic drugs may improve immune cell function in aged and patients undergoing cancer treatment.\n                  <\/jats:p>","DOI":"10.1111\/acel.12971","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T03:57:47Z","timestamp":1559275067000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Restored immune cell functions upon clearance of senescence in the irradiated splenic environment"],"prefix":"10.1111","volume":"18","author":[{"given":"Lina","family":"Palacio","sequence":"first","affiliation":[{"name":"Centre de recherche du CHU Ste\u2010Justine Montreal Quebec Canada"},{"name":"D\u00e9partement de pharmacologie et physiologie, Facult\u00e9 de M\u00e9decine Universit\u00e9 de Montr\u00e9al Montreal Quebec 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