{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:45:26Z","timestamp":1790689526283,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"publisher","award":["ZYLX201837"],"award-info":[{"award-number":["ZYLX201837"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571230"],"award-info":[{"award-number":["81571230"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cerebral amyloid beta (A\u03b2) deposits are the main early pathology of Alzheimer's disease (AD). However, abundant A\u03b2 deposits also occur spontaneously in the brains of many healthy people who are free of AD with advancing aging. A crucial unanswered question in AD prevention is why AD does not develop in some elderly people, despite the presence of A\u03b2 deposits. The answer may lie in the composition of A\u03b2 oligomer isoforms in the A\u03b2 deposits of healthy brains, which are different from AD brains. However, which A\u03b2 oligomer triggers the transformation from aging to AD pathogenesis is still under debate. Some researchers insist that the A\u03b2 12\u2010mer causes AD pathology, while others suggest that the A\u03b2 dimer is the crucial molecule in AD pathology. Aged rhesus monkeys spontaneously develop A\u03b2 deposits in the brain with striking similarities to those of aged humans. Thus, rhesus monkeys are an ideal natural model to study the composition of A\u03b2 oligomer isoforms and their downstream effects on AD pathology. In this study, we found that A\u03b2 deposits in aged monkey brains included 3\u2010mer, 5\u2010mer, 9\u2010mer, 10\u2010mer, and 12\u2010mer oligomers, but not 2\u2010mer oligomers. The A\u03b2 deposits, which were devoid of A\u03b2 dimers, induced glial pathology (microgliosis, abnormal microglia morphology, and astrocytosis), but not the subsequent downstream pathologies of AD, including Tau pathology, neurodegeneration, and synapse loss. Our results indicate that the A\u03b2 dimer plays an important role in AD pathogenesis. Thus, targeting the A\u03b2 dimer is a promising strategy for preventing AD.<\/jats:p>","DOI":"10.1111\/acel.12978","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T04:12:37Z","timestamp":1559707957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Brains of rhesus monkeys display A\u03b2 deposits and glial pathology while lacking A\u03b2 dimers and other Alzheimer's pathologies"],"prefix":"10.1111","volume":"18","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"Innovation Center for Neurological Disorders Xuan Wu Hospital, Capital Medical University Beijing China"},{"name":"Department of Neurobiology, School of Basic Medical Sciences Capital Medical University Beijing China"},{"name":"Laboratory Animal Center Capital Medical University Beijing 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