{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:49:12Z","timestamp":1768913352482,"version":"3.49.0"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005880","name":"National Institute of Biological Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19-AG023122, R21AG056630, R01AG061844, 263 MD 9164, and 263 MD 821336"],"award-info":[{"award-number":["U19-AG023122, R21AG056630, R01AG061844, 263 MD 9164, and 263 MD 821336"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The discovery of treatments to prevent or delay dementia and Alzheimer's disease is a priority. The gene <jats:italic>APOE<\/jats:italic> is associated with cognitive change and late\u2010onset Alzheimer's disease, and epidemiological studies have provided strong evidence that the <jats:italic>e<\/jats:italic><jats:sub>2<\/jats:sub> allele of <jats:italic>APOE<\/jats:italic> has a neuroprotective effect, it is associated with increased longevity and an extended healthy lifespan in centenarians. In this study, we correlated <jats:italic>APOE<\/jats:italic> genotype data of 222 participants of the New England Centenarian Study, including 75 centenarians, 82 centenarian offspring, and 65 controls, comprising 55 carriers of <jats:italic>APOE<\/jats:italic> <jats:italic>e<\/jats:italic><jats:sub>2<\/jats:sub>, with aptamer\u2010based serum proteomics (SomaLogic technology) of 4,785 human proteins corresponding to 4,137 genes. We discovered a signature of 16 proteins that associated with different <jats:italic>APOE<\/jats:italic> genotypes and replicated the signature in three independent studies. We also show that the protein signature tracks with gene expression profiles in brains of late\u2010onset Alzheimer's disease versus healthy controls. Finally, we show that seven of these proteins correlate with cognitive function patterns in longitudinally collected data. This analysis in particular suggests that Baculoviral IAP repeat containing two (BIRC2) is a novel biomarker of neuroprotection that associates with the neuroprotective allele of <jats:italic>APOE<\/jats:italic>. Therefore, targeting <jats:italic>APOE<\/jats:italic> <jats:italic>e<\/jats:italic><jats:sub>2<\/jats:sub> molecularly may preserve cognitive function.<\/jats:p>","DOI":"10.1111\/acel.13023","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T05:45:17Z","timestamp":1565070317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["A serum protein signature of <i>APOE<\/i> genotypes in centenarians"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6419-1545","authenticated-orcid":false,"given":"Paola","family":"Sebastiani","sequence":"first","affiliation":[{"name":"Department of Biostatistics Boston University School of Public Health Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Monti","sequence":"additional","affiliation":[{"name":"Bioinformatics Program Boston University Boston 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Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Glass","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research Cambridge Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas T.","family":"Perls","sequence":"additional","affiliation":[{"name":"Geriatrics Section, Department of Medicine, School of Medicine and Boston Medical Center Boston University Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000022"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-9-S2-S8"},{"issue":"2","key":"e_1_2_6_4_1","first-page":"111","article-title":"The telephone interview for cognitive status","volume":"1","author":"Brandt J.","year":"1988","journal-title":"Neuropsychiatry, 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