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Using a protocol intended to regenerate the thymus, we observed protective immunological changes, improved risk indices for many age\u2010related diseases, and a mean epigenetic age approximately 1.5\u00a0years less than baseline after 1\u00a0year of treatment (\u22122.5\u2010year change compared to no treatment at the end of the study). The rate of epigenetic aging reversal relative to chronological age accelerated from \u22121.6\u00a0year\/year from 0\u20139\u00a0month to \u22126.5\u00a0year\/year from 9\u201312\u00a0month. The GrimAge predictor of human morbidity and mortality showed a 2\u2010year decrease in epigenetic vs. chronological age that persisted six months after discontinuing treatment. This is to our knowledge the first report of an increase, based on an epigenetic age estimator, in predicted human lifespan by means of a currently accessible aging intervention.<\/jats:p>","DOI":"10.1111\/acel.13028","type":"journal-article","created":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T22:03:36Z","timestamp":1567980216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":478,"title":["Reversal of epigenetic aging and immunosenescent trends in humans"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0445-7385","authenticated-orcid":false,"given":"Gregory M.","family":"Fahy","sequence":"first","affiliation":[{"name":"Intervene Immune Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8492-5198","authenticated-orcid":false,"given":"Robert T.","family":"Brooke","sequence":"additional","affiliation":[{"name":"Intervene Immune Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Watson","sequence":"additional","affiliation":[{"name":"UCLA Division of Plastic and Reconstructive Surgery David Geffen School of Medicine Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2343-5771","authenticated-orcid":false,"given":"Zinaida","family":"Good","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Immunology Stanford University Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1999-6595","authenticated-orcid":false,"given":"Shreyas S.","family":"Vasanawala","sequence":"additional","affiliation":[{"name":"Stanford Medical Center Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holden","family":"Maecker","sequence":"additional","affiliation":[{"name":"Institute for Immunity, Transplantation and Infection, Stanford School of Medicine Human Immune Monitoring Center Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5389-0906","authenticated-orcid":false,"given":"Michael D.","family":"Leipold","sequence":"additional","affiliation":[{"name":"Institute for Immunity, Transplantation and Infection, Stanford School of Medicine Human Immune Monitoring Center Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5695-9446","authenticated-orcid":false,"given":"David T. 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