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Synaptic plasticity and associative plasticity, the cellular basis of memory, are impaired in AD. Recent studies suggest a functional relevance of microRNAs (miRNAs) in regulating plasticity changes in AD, as their differential expressions were reported in many AD brain regions. However, the specific role of these miRNAs in AD has not been elucidated. We have reported earlier that late long\u2010term potentiation (late LTP) and its associative mechanisms such as synaptic tagging and capture (STC) were impaired in A\u03b2 (1\u201342)\u2010induced AD condition. This study demonstrates that expression of miR\u2010134\u20105p, a brain\u2010specific miRNA is upregulated in A\u03b2 (1\u201342)\u2010treated AD hippocampus. Interestingly, the loss of function of miR\u2010134\u20105p restored late LTP and STC in AD. In AD brains, inhibition of miR\u2010134\u20105p elevated the expression of plasticity\u2010related proteins (PRPs), cAMP\u2010response\u2010element binding protein (CREB\u20101) and brain\u2010derived neurotrophic factor (BDNF), which are otherwise downregulated in AD condition. The results provide the first evidence that the miR\u2010134\u2010mediated post\u2010transcriptional regulation of CREB\u20101 and BDNF is an important molecular mechanism underlying the plasticity deficit in AD; thus demonstrating the critical role of miR\u2010134\u20105p as a potential therapeutic target for restoring plasticity in AD condition.<\/jats:p>","DOI":"10.1111\/acel.13046","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T06:15:18Z","timestamp":1571379318000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["MicroRNA\u2010134\u20105p inhibition rescues long\u2010term plasticity and synaptic tagging\/capture in an A\u03b2(1\u201342)\u2010induced model of Alzheimer\u2019s disease"],"prefix":"10.1111","volume":"19","author":[{"given":"Nimmi","family":"Baby","sequence":"first","affiliation":[{"name":"Department of Physiology Yong Loo Lin School of Medicine National 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